Necrosis and Apoptosis

During embryonic and postnatal development, and throughout adult life, many cells in the nervous system die 603 

Many of the morphological and biochemical changes that occur in cells that die by necrosis are very different from those that occur in apoptosis 604 

Adaptive apoptosis occurs in the developing and adult nervous system 604 

Once apoptosis is triggered, a stereotyped sequence of premitochondrial events occurs that executes the death process 609 

Several different changes in mitochondria occur during apoptosis 610 

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Acute over-activation of NHE1 results in a marked elevation in intracellular sodium concentration with a subsequent increase in intracellular calcium, via the Na +/Ca++ exchanger. This in turn triggers a cascade of injurious events that can culminate in tissue dysfunction and ultimately apoptosis and necrosis. This is commonly seen in organs such as the heart, brain and kidneys as a consequence of ischemia-reperfusion. 

Capaccioh, S., and Orlandini, S. Z., 2000, Aponecrosis morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis, J. Cell Physiol. 182 41-49. 

Meilhac, O., Escargueil-Blanc, 1., Thiers, J.C., Salvayre, R., and Negre-Salvayre, A., 1999, Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density hpoproteins, EASES J. 13 485-494. 

Abrahamsen, J.F., Bakken, A.M. and Bmsemd Q. (2002) Cryopreserving human peripheral blood progenitor cells with 5-percent rather than 10-percent DMSO results in less apoptosis and necrosis in CD34+ cells. Transfusion 42 1573-1580. 

Growth and Death of Cells and Humans The Cell Cycle, Apoptosis and Necrosis... 

CH 20 GROWTH AND DEATH OF CELLS AND HUMANS THE CELL CYCLE, APOPTOSIS AND NECROSIS... 

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