Aphrodisiac

Acid anhydrides rarely occur naturally One example is the putative aphrodisiac can thandm obtained from a species of beetle... 

Yohimbine (104), also from the bark of C.johimbe K Schum. and from the roots of R. serpentina (1. ) Benth. has a folk history (unsubstantiated) of use as an aphrodisiac. Its use has been confirmed experimentally as a local anesthetic, with occasional employment for rehef ia angiaa pectoris and arteriosclerosis, but is frequently contraindicated by its undesired renal effects. Yohimbine and some of its derivatives have been reported as hahuciaogenic (70). In addition, its pattern of pharmacological activities ia a variety of animal models is so broad that its general use is avoided. All ten carbon atoms of secologanin (102) as well as the entire skeleton of tryptamine (98, R = H) are clearly seen as iatact portions of this alkaloid. 

Hesse and Langer say that as a vasodilator yohimbine is the most potent, followed by j9- and a-yohimbines, yohimbene and aitoyohimbine in descending order. Yohimbine is principally used in veterinary medicine as an aphrodisiac. ... 

Zeugungs-. generative, procreative. -flUssIg-keit,/. seminal fiuid. -mittel, n. aphrodisiac, -stoff, m. semen. 

The Vesper has a reputation for being an aphrodisiac, but what wouldn t with a short list of strong liquors in it ... 

Briand L., Huet J., Perez V., Lenoir G., et al. (2000). Odorant and pheromone binding by aphrodisin, a hamster aphrodisiac protein. FEBS Letts 476, 179-185. 

Singer A.G., Clancy A.N. and Macrides F. (1989). Conspecific and heterospecific proteins related to aphrodisin lack aphrodisiac activity in male hamsters. Chem Senses 14, 563-576. 

Yohimbine (36) is a well-known and reasonably available alkaloid from Corynanthe yohimbe, inter alia. For this reason, and partly because of its intrinsic pharmacological activity (including reputed aphrodisiac activity), chemists have frequently studied its properties. Oppenauer oxidation is usually attended by saponification and decarboxylation in this series, and yohimbone (37) is the product. Wolf-Kischner reduction to yohimbane (38), followed by sodium hydride mediated alkylation, leads to the analgesic agent, mimbane (39). °... 

It is medicinally used from Korea to Cambodia, Laos, and Vietnam. In Korea, the plant is used as an aphrodisiac for males and the elderly. In Japan, a decoction of the root is drunk to treat cough, invigorate, and treat tuberculosis. In Taiwan, the plant is an external remedy for snake bites. In Cambodia, Laos, and Vietnam, the roots are used to treat bronchitis, amnesia, and to stimulate memory and urination. The antitussive property is very probably owed to polygalasaponins, which are known to abound in the plant (24-26). It would be interesting to know whether the tonic properties mentioned here are owed to serotoninergic mechanisms. What is the alkaloidal content of this herb ... 

Gauthaman K, Adaikan PG, Prasad RNV. Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 2002 71 1385-1396. 

The plant is used in elaborate religious ceremonies, which vary from area to area. Adherents use the plant to communicate spiritually with their ancestors. In lower doses, it is used to counteract fatigue and hunger. Warriors and hunters have used it to remain awake at night. Some Europeans have claimed that it has aphrodisiac effects as well. More recently, anecdotal reports have indicated possible antiaddictive effects of iboga, stimulating a rush of scientific research into the neurochemical effects of the plant (Mash et al. 1998). 

Sachs, B. D. (1999). Airborne aphrodisiac odor from estrous rats implications for pheromonal classification. InAdvances in Chemical Signals in Vertebrates, vol. 8, ed. R. E. Johnston, D. Miiller-Schwarze, and P. W. Sorensen, pp. 333-342. New York Kluwer Academic-Plenum. 

Aphrodisiac, reputed, 347 Appetite depressants, 47 Aprindine, 208 Arbuzov reaction, 420 Aromatization, by loss of methyl group, 147, 149 Arrhythmias, cardiac, 33 Aspirin, 63, 89 Atenolol, 109... 

Yohimbine can be found in drugs such as Aphrodyne or Yohimex. About 20 different products containing this alkaloid have been developed. These drugs are aphrodisiacs used to treat impotency and impotency-related problems in men. 

Danaidone (25), which was first isolated from Lycorea ceres ceres (55) and Danaus gilippus berenice 59) by J. Meinwald et al., has been shown to act as an aphrodisiac pheromone necessary for successful courtship in D. gilippus berenice (57) and in D. chrysippus (56), since danaidone-lacking males have reduced courtship success 57,60). It seems likely that a similar role will be found for the closely related aldehydes, hydroxydanaidal (26) and danaidal (27). 

United States. Fluidextract of the inflorescence is taken orally as a narcotic, antispas-modic, analgesic, and aphrodisiac " . Hot water extract of the flowering top is taken orally as a potent antispasmodic, anodyne, and narcotic. One teaspoon of plant material is steeped in 2 cups of boiling water, and 1 tablespoonful is taken two to four times a day " ". The dried aerial parts are smoked by both sexes as an aphrodisiac " . 

Aphrodisiac activity. The leaf, smoked by adults of both sexes, was active . Attention deficit hyperactivity disorder. 

CS171 Gawin, F. H. Drugs and Eros Reflection on aphrodisiacs. J Psychedelic Drugs 1978 10 227-236. 

---