Aortic pressure sodium nitroprusside

Popovic Z.B., Khot U.N., Novaro G.M., Casas E, Greenberg N.L., Garcia M.J., Francis G.S., and Thomas J.D. 2005. Effects of sodium nitroprusside in aortic stenosis associated with severe heart failure pressure-volume loop analysis using a numerical model. Am. J. Physiol. Heart Circ. Physiol. 288(1) H416-23. Epub 2004 Sep 2. 

In Apo E-KO mice. All treatment accelerated atherosclerosis in the carotid artery, increased blood pressure, increased arterial stiffening, increased pulse wave velocity, and decreased arterial elasticity. These functional changes were correlated with morphological and biochemical changes as demonstrated by an increase in collagen content, a decrease in elastin content, and breaks in the internal elastic lamina in the aortic wall. In addition, endothelium-independent vasorelaxation to sodium nitroprusside was impaired (265). 

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