Anxiety knockout mouse studies

Observational studies Tetracyclines, especially minocycline, inhibit the matrix metal-loproteinases (MMPs), and this has been studied in patients with the so-called fragile X syndrome (MIM 300624), an inherited form of intellectual disability and autism, with an estimated prevalence of about 1 in 4000 [125. The gene responsible is located on the X chromosome (Xq27.3) and is called Fragile X Mental Retardation-1 (FMRl MIM 309550) [126 ]. Minocycline improved behavioral performance and reduced anxiety in a FMRI knockout mouse [127 ], and has been studied in an open trial in 20 patients with the fragile X syndrome, aged 13-32 years [128 ]. The... 

Redrobe JP, Dumont Y, Fournier A, Quirion R (2002a) The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neiuopsychopharmacology 26 615-624 Redrobe JP, Dmnont Y, Quirion R (2002b) Neiuopeptide Y (NPY) and depression From animal studies to the hmnan condition. Life Sci 71 2921-2937 Redrobe JP, Dmnont Y, Herzog H, Quirion R (2003) Neiuopeptide Y (NPY) Y2 receptors mediate behaviour in two animal models of anxiety evidence from Y 2 receptor knockout mice. Behav Brain Res 141 251-255... 

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