Antitumor mechanism

The above three equations (Eqs. 10-12) for the different cell lines are very similar to each other, which suggests that the inhibition against DNA topo I is probably one of the most important antitumor mechanisms for these compounds (CPT, CPT-11, SN-38, TPT, and EGCG) against the three human colon carcinoma (HCT 116, VACO 241, and SW 480) cell lines. In these equations, the number of data points (four or five) is small, but the correlations are statistically significant. 

Takatori S, et al. Antitumor mechanisms and metabolism of the novel antitumor nucleoside analogues, l-(3-C-ethynyl-P-D-ribo-pentofuranosyl) cytosine and 1-(3-C-ethynyl-P-D-ribo-pentofuranosyl)uracil. Cancer Chemother Pharmacol 1999 44 97. 

Nanba and Kuroda studied the antitumor mechanisms of the orally administered edodes to mice and observed significant inhibition of... 

The effect of combretastatin A-4 on the growth and metastasis of gastric cancer cells at clinically achievable concentration and the associated antitumor mechanisms... 

Martin, M. L, Barcelo-Coblijn, G., De Almeida, R. F. M., Noguera-Salva, M. A., Teres, S., Higuera, M., Liebiseh, G., Sehmitz, G., Busquets, X. Escriba, P. V. (2013). The role of membrane fatty aeid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid. Biochimica et Biophysica Acta-Biomembranes, 1828(5), 1405-13. 

The most studied activity for mistletoe over the last decade is its antitumor effect. Numerous reports have been published on its efficacy in various human cancer conditions, and against many tumors and cancer cell lines in vivo and in vitro, respectively. " Antitumor mechanisms involve the immunomodulatory effect mentioned above for lectins, as well as apoptosis, antiangiogenesis, cell cycle disruption, and direct cytotoxic effects on cancer cells. ... 

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