Antitumor activity inoculated leukemia

Fig. 8. Antitumor activity of vinepidine, vincristine, and vinblastine against P388 leukemia. Compounds were administered i.p. as their sulfate salts on day I following i.p. inoculation of I X 10 tumor cells.

It was observed that macbecins I (93) and II (94) were moderately active against several Gram-positive bacteria and fungi, [149,205] whereas macbecin I (93) exhibited marked antitumor activity against intraperitoneally (ip) inoculated leukemia P388, B16 melanoma and Ehrlich s carcinoma in mice on ip administration [152]. According to this report, the maximum effect measured in terms of ILS (increase of life span) was 97% at a daily dose level of 10 mg/kg for leukemia P388, 103% at 5... 

Pandey et al. in 1981 while working in the Frederic Cancer Research Centre, Maryland reported the isolation [49] from the fermentation broth of Streptomy-ces grieseus, a tan red colour quinonoid compound, exhibiting antibacterial, antifungal, cytotoxic, and antitumor activity in a variety of in vitro screens [50]. The structure of this compound, appropriately named as fredericamycin A, was established as 67 by X-ray crystallographic analysis coupled with NMR and mass spectral data [51]. Fredericamycin A in vivo substantially increases long term survival of mice inoculated with enriched carcinoma and P388 leukemia cells. 

Recently it was demonstrated that transfection of tumor cells with an antitumor peptide induced a protective immune reponse. Inoculation of mice with murine BD-2-transfected leukemia cells enhanced cytotoxic T lymphoc)des (CTL) and natural killer (NK) anti-tumor activity, with augmented IL-12 and IFN-y production. Animals vaccinated with transfected cells were protected against a challenge with parental cells (50% protection) and the vaccination generated leukemia-specific memory CTL [210]. 

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