Antipyretic analgesics interaction

Non-steroidal antiinflammatory drugs (NSAIDs) are also known as nonopioid analgesics. They relieve pain without interacting with opioid receptors and do not depress CNS and have no drug dependence or drug abuse property and possess antipyretic activity also. They act primarily on peripheral pain mechanisms and also in CNS to raise pain threshold. 

Nelson SD. Analgesic-antipyretics. In Levy RH, Thummel KE, Trager WF, et al., eds. Metabolic Drug Interactions. Philadelphia Lippincott Williams and Wilkins, 2000 447 155. 

Langmuir monolayers of calixarenes have also been studied for their ability to bind small organic molecules. Recently, we reported on the ability of Langmuir monolayers of an amphiphilic p-amidophenolcalix[4]arene derivative to interact with acetaminophen (APAP) [34, 49], an active pharmaceutical ingredient (API) widely used as analgesic and antipyretic, at the air-water interface. Interestingly, these calixarene-based surfaces act as templates for the interfacial crystallization of the pharmaceutical (Fig. 37.7) [34]. The similarity between the polar functions of the amphiphUe and the stmcture of APAP were shown to favor the molecular recognition event. 

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