Death antipsychotic drugs

Titier, K., Canal, M., Deridet, E., Abouelfafh, A., Gromb, S., Molimard, M. and Moore, N. (2004) Determination of myocardium to plasma concentration ratios of five antipsychotic drugs comparison with their ability to induce arrhythmia and sudden death in clinical practice. Toxicology and Applied Pharmacology, 199, 52-60. 

Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia meta-analysis of randomized placeho-controUed trials. JAMA 2005 294(15) 1934-43. 

Glassman AH, Bigger JT, Jr. Antipsychotic drugs prolonged QTc interval, torsades de pointes, and sudden death. / m J Psychiatry 2001 158 1774-1782. 

Antipsychotic drugs directly affect the hypothalamus and suppress temperature regulation. Severe hyperthermia, rhahdomyolysis, renal failure, and death may result. A cool environment and adequate amounts of fluids are mandatory for patients taking antipsychotic agents. 

Medline Plus. (2007, June 5). HealthDay news Antipsychotic drugs raise death rates in elderly. Retrieved from http //www.nlm.nih.gov/medlineplus... 

Stroke is a matter of increasing concern with some antipsychotic drugs, and the Canadian Medicine Agency has issued a warning that there is a risk of stroke with risperidone (116). On April 2005, the FDA issued an alert and asked the company to add the following information to both the oral and depot formulations The FDA has found that older patients treated with atypical neuroleptic drugs for dementia had a higher chance for death than patients who did not take the medicine. This is not an approved use (117). In some countries, the use of... 

Sertindole is an antipsychotic drug that was approved in several countries in 1997, but was suspended in January 2000, following concerns about reports of cardiac dysrhythmias and sudden death (SEDA-22, 71) (SEDA-25, 71) (1). To gather further information, data collected for... 

Thomas SH, Cooper PN. Sudden death in a patient taking antipsychotic drugs. Postgrad Med J 1998 74(873) 445-6. 

In a retrospective study of cases from the Jefferson County Coroner/Medical Examiners Office, Alabama, USA between January 1982 and December 2000 there were 101 deaths in patients in whom methadone was detected in the blood (35). Methadone was the sole intoxicant in 15 cases, with a mean concentration of 0.27 pg/ml. A benzodiazepine was the most frequently detected co-intoxicant in 60 of the 101 cases and the only co-intoxicant in another 30 cases. In 26 cases methadone had been taken with a range of non-benzodiazepine substances, including antidepressants, antipsychotic drugs, antiepileptic drugs, and cocaine. The high... 

Classman A H, Bigger J T 2001 Antipsychotic drugs Prolonged QTc interval. Torsade de pointes, and sudden death. American Journal of Psychiatry 158 1774-1782... 

Death Deaths associated with commonly prescribed antipsychotic drugs [SEDA-32, 89 SEDA-33, 90] have been assessed in a 5-year retrospective study using US Veterans National Healthcare data [54 ]. The exposed subjects, who were predominantly male, aged 65 and older and with a diagnosis of dementia, were compared with randomly selected controls. Those who were exposed to haloperidol (n = 2217), olanzapine ( = 3384), quetiapine (n = 4277), or risperidone ( = 8249) had more co-morbidities than the controls. During the first 30 days, there was a significant increase in mortality in those who took doses of haloperidol over 1 mg/day (HR=3.2 95% Cl = 2.2, 4.5), olanzapine over 2.5 mg/day (HR = 1.5 95% CI=1.1, 2.0), or risperidone over 1 mg/day... 

Psychiatric The incidence of suicide-related events in patients with schizophrenia or bipolar disorder taking aripiprazole has been studied using administrative data from three US sources [65 "]. Suicide attempts and death by suicide were assessed in patients aged at least 18 years. Among 20489 antipsychotic drug users (8985 patient-years), unadjusted suicide event rates per 1000 patient-years were 21 for aripiprazole 24 for olanzapine 32 for quetiapine 20 for risperidone and 49 for ziprasidone. Compared with current users of the other antipsychotic... 

Death Current evidence does not link clozapine to increased mortality rates indeed, this drug seems to be better than other antipsychotic drugs in this regard [87 ]. 

Sicouri S, Antzelevitch C. Sudden cardiac death secondary to antidepressant and antipsychotic drugs. Expert Opin Drug Saf 2008 7(2) 181-94. 

Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 2009 360(3) 225-35. 

Cicconi M, MangiulK T, Bolino G. Death connected to paralytic ileus due to the intake of antipsychotic drugs. Case report. Romanian J Leg... 

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