Antimycoplasmal activity

Pijper, P. J. Synthesis and Antimycoplasmal Activity of Compounds Structurally Related to 2,2 -Bipyridyl. Ph.D. Thesis, Free University Amsterdam 1980... 

Amino-2 -deoxypurincs. 2 -Amino-2 -deoxyadenosine (15) is a naturally occurring N-nucleoside isolated from Actinomadura that shows antimycoplasmal activity (1,4). Adenosine is the direct precursor for its biosynthesis (30). 2 -Amino-2 -deoxyguanosine (16), isolated from a strain of Enterobacter cloacae (1,4), shows the growth of HeLa S3 cells and Sarcoma 180 in vivo and has been tested for antibacterial activity. 

It has been known for many years that the onset of inflammatory diseases may follow or occur along with a variety of infections. As a result, it is of interest that copper complexes have antiviral, antibacterial, antiprotozoal, anthelmintic, antifungal, antialgal and antimycoplasmal activities. 

Furneri, P.M., D. Paolino, A. Saija et al., 2006. In vitro antimycoplasmal activity of Melaleuca alternifolia essential oil. J. Antimicrob. Chemother., 58 706-707. 

Fumeri PM et al (2002) In vitro antimycoplasmal activity of oleuropein. Int J Antimicrob Agents 20 293-296... 

Fabiani, R. et al.. Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis. Fur. J. Cancer Prev., 11, 351, 2002. Fumeri, P.M. et al., Antimycoplasmal activity of hydroxytyiDsol, Antimicrobial agents and chemotherapy, 48, 4892, 2004. 

The naturally occurring nucleoside analogues discussed in this section contain the IV-glycosyl linkage and either purine, pyrimidine, imidazole, diazepin, or indole rings. The purine nucleosides inhibit protein synthesis, RNA and DNA synthesis, and methyltransferases they have antimycoplasmal, antiviral, hypotensive, antifungal, antimycobacterial, and antitumor activities and induce sporulation (1—4). The pyrimidine nucleosides inhibit protein synthesis, virus replication, RNA and DNA synthesis, and cAMP phosphodiesterase. The imidazole nucleosides inhibit nucleic acid synthesis. The diazepin nucleosides inhibit adenosine deaminase (ADA). The indole nucleosides inhibit bacteria, yeast, fungi, and viruses. 

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