Antimitogenic signal

Polyak, K., Lee, M., Erdjement-Bromage, H., Koff, A., Roberts, J., Tempst, P., and Massague, J. (1994). Cloning of p27 , a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.. Cell 79, 59-66. 

A cell can enter various stages depending on the intensity and balance of mitogenic and antimitogenic signals (Fig. 14.1) ... 

Many different factors may be involved in triggering apoptosis, some of which are also components of mitogenic or antimitogenic signaling pathways. 

The product of the retinoblastoma gene, the retinoblastoma protein pRb, functions as a switch for conversion of mitogenic and antimitogenic signals at the transcription... 

Antimitogenic Signals during Cell-Cell Communication... 

In the absence of external mitogenic signals or in the presence of a majority of antimitogenic signals, cell division activity may be stopped. The cell enters the quiescent phase (G0 phase). From G0 phase, cell division may be resumed when mitogenic signals reappear. 

Another route that a cell can take is the pathway of programmed cell death, or apoptosis (see Chapter 15). Many different factors may be involved in triggering apoptosis, some of which are also components of mitogenic or antimitogenic signaling pathways. 

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