Antimicrobial phenylethyl

Phenylethyl alcohol is used as an antimicrobial preservative in nasal, ophthalmic, and otic formulations at 0.25-0.5% v/v concentration it is generally used in combination with other preservatives.Phenylethyl alcohol has also been used on its own as an antimicrobial preservative at concentrations up to 1% v/v in topical preparations. At this concentration, mycoplasmas are inactivated within 20 minutes, although enveloped viruses are resistant. " Phenylethyl alcohol is also used in flavors and as a perfumery component, especially in rose perfumes. 

Incompatible with oxidizing agents and protein, e.g., serum. Phenylethyl alcohol is partially inactivated by polysorbates, although this is not as great as the reduction in antimicrobial activity that occurs with parabens and polysorbates. ... 

Beilstein Handbook Reference) AI3-00744 Benzeneethanol Benzylcarbinol Benzyi-methanol BRN 1905732 Caswell No. 655C EINECS 200-466-2 EPA Pesticide Chemical Code 001503 Ethanol, 2-phenyl- FEMA No. 2858 FEMA Number 2858 p-Fenethylalkohol P-Fenylethanol HSDB 5002 p-Hydroxyethylbenzene Methanol, benzyl- NSC 406252 PEA Phenethanol p-Phenylethanol Phenethyl alcohol Phenylethyl alcohol. Has the smell of roses. Used In perfumery and as an antimicrobial agent. Clear liquid mp= -27° bp760 = 219-221° dS = 1.017 n6 = 1.530 soluble in H2O (2 g/100 ml), mote soluble in organic solvents LDso (rat orl)= 1790 mg/kg. Lancaster Synthesis Co. Sigma-Aldrich Fine Chem. 

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