Antimicrobial agents beta-lactam

Tanaka G, Shigeta M, Komatsuzawa H, et al. Effect of the growth rate of Pseudomonas aeruginosa biofllms on the susceptibility to antimicrobial agents beta-lactams and fluoroquinolones. Chemotherapy Iaimwy 1999 45(l) 28-36. 

Reading, C. and Cole, M. (1977) Clavulanic acid a beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus. Antimicrobial Agents and Chemotherapy, 11, 852—857. 

A number of antibiotics have been used as aerosol therapies. Examples include beta lactam agents, polymycin antimicrobials, neomycin, gentamicin, and tobramycin. Many of the early efforts were reported as case studies, and observations and data regarding safety and efficacy were lacking. Controlled clinical trials were not conducted until the middle of the 1980s. More recent evaluations have focused on the role of inhaled tobramycin used as suppressive therapy for cystic fibrosis patients colonized with Pseudomonas aeruginosa. 

Nakae, T., Nakajima, A., Ono, T., Saito, K., and Yoneyama, H. (1999) Resistance to beta-lactam antibiotics in Pseudomonas aeruginosa due to interplay between the MexAB-OprM efflux pump and beta-lactamase. Antimicrobial Agents and Chemotherapy, 43 (5), 1301-1303. 

Darveau RP. Cunningham MD, Seachord CL, Cassiano-Clough L, Cosand WL, Blake J, Watkins CS, Beta-lactam antibiotics potentiate magainin 2 antimicrobial activity in vitro and in vivo. Antimicrob Agents Chemother 1991 35 1153-1159. 

H. pylori has been demonstrated to be sensitive to a wide variety of antimicrobial agents, including macrolides, beta lactams, ketoconazoles, tetracyclines, gentamycin, rifampicin, nitrofuran, and some quinolones. Nevertheless, the use of any of these agents alone (monotherapy) has generally proved to... 

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