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Antimalarials adverse effects

Weekly dosing with mefloquine for chemoprophylaxis may cause nausea, vomiting, dizziness, sleep and behavioral disturbances, epigastric pain, diarrhea, abdominal pain, headache, rash, and dizziness. Neuropsychiatric toxicities have received a good deal of publicity, but despite frequent anecdotal reports of seizures and psychosis, a number of controlled studies have found the frequency of serious adverse effects from mefloquine to be no higher than that with other common antimalarial chemoprophylactic regimens. Leukocytosis, thrombocytopenia, and aminotransferase elevations have been reported. [Pg.1126]

Chloroquine and related antimalarials are effective in rheumatoid arthritis and lupus erythematosus, but their mode of action is not known. The anthelmintic drug levamisole (186) is also effective but adverse effects limit its use. [Pg.173]

There was a high frequency of amphetamine abuse and withdrawal among patients from the Thai-Myanmar border area admitted to hospital with Plasmodium falciparum malaria (90). This co-morbidity can cause diagnostic confusion, alter malaria pathophysiology, and lead to drug interactions. Considering the potential neuropsychiatric adverse effects of mefloquine, an important component of current antimalarial treatment in Southeast Asia, it should be avoided in patients who abuse amphetamines. [Pg.461]

A postal survey of the incidence of psychiatric disturbances in 2500 returning Israeli travellers (505) showed that travellers with this class of adverse effects were more likely to have taken mefloquine than other antimalarial drugs. Of 117 travellers with psychiatric adverse effects, 115 had taken mefloquine compared with 948/1340 for the entire cohort. This was a retrospective postal study with a response rate of 54% (1340 out of 2500), and of those who responded 71% had taken mefloquine, 5% had taken chloroquine, and 24% had taken no prophylaxis. In this study 11% (117) of the respondents reported psychiatric disturbances, mainly sleep disturbance, fatigue, vivid dreams, or lack of mood. Only 16 of the respondents had symptoms lasting 2 months or more. Those who had had a psychiatric disturbance were also more likely to have been female and to have taken recreational drug use. [Pg.686]

ARTEMETHER WITH LUMEFANTRINE H2 RECEPTOR BLOCKERS -CIMETIDINE t efficacy and adverse effects of antimalarials Inhibition of metabolism, some definitely via CYP3A4 Avoid co-administration... [Pg.581]

Gastrointestinal adverse effects are more common with halofantrine than with other antimalarial drugs (11). [Pg.1574]

The adverse effects of mefloquine have been extensively reviewed both for prophylaxis (when rare neuropsychiatric adverse effects make its use controversial) and in treatment doses, when it has been linked to an increased incidence of the postmalaria neurological syndrome. A retrospective review of 5120 Itahan soldiers showed an overall chemoprophylaxis curtailment rate of less than 1%, which was not significantly different from the combination of chloroquine and proguanil (11). A semi-systematic review also suggested no significant difference in tolerabihty compared with other antimalarial drugs (12). [Pg.2233]

However, a further study of 208 pregnant women on the Thai-Burmese border showed a significantly increased incidence of still-births compared with 1565 women treated with other antimalarial drugs (51). Other adverse effects were no more common than with other antimalarial drugs. The study was performed during a period of emerging mefloquine-resistant malaria, and the findings may also reflect the effect of suboptimal malaria treatment. [Pg.2235]

For the antimalarial drugs, however, essential data are available in the literature. Many of the antimalarials investigated have a large apparent distribution volume (Vd) and a long elimination half-life (t1/2) (Table 10.1). This reflects accumulation of the drugs in body tissues. Most of the adverse effects associated with the use of antimalarials are related to the eye and skin. The retina is richly supplied with blood vessels, but the blood-retinal barrier is normally very tight and therefore restricts... [Pg.227]


See other pages where Antimalarials adverse effects is mentioned: [Pg.25]    [Pg.220]    [Pg.434]    [Pg.1130]    [Pg.220]    [Pg.553]    [Pg.346]    [Pg.991]    [Pg.345]    [Pg.2232]    [Pg.3003]    [Pg.244]    [Pg.1588]    [Pg.24]    [Pg.218]    [Pg.215]    [Pg.210]    [Pg.220]    [Pg.666]   
See also in sourсe #XX -- [ Pg.1912 ]

See also in sourсe #XX -- [ Pg.210 ]




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Antimalarial

Antimalarial effects

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