Antiherpetic activity

Another interesting use of the imidazylate gr up in the furanoside series has been described by Tann et al. [89]. Thus, treatment of the C-2 imidazylate ester of the a-D-ribofuranoside tribenzoate derivative with KHF2 and HF, at 160°C, led to the 2-deoxy-2-fluoro sugar in 63% yield, presumably through the intermediacy of the fluorosulfate ester (HPLC). The 2-fluoro compound is a key intermediate in the preparation of 2 -fluoro-2 -deoxy D-arabinofuranosyl pyrimidine nucleosides, which exhibit powerful antiherpetic activity [89] (Scheme 12). 

Fig. (14). Structure-Antiherpetic Activity Relationships of Oleanene Glucuronides...

I express my appreciation to Dr. H. K. Lee of Korea Research Institute of Bioscience and Biotechnology for measurement of anti-complementary activity. I am grateful to Dr. K. Yokomizo and Prof. M. Uyeda in this faculty for measurement of antiherpetic activity. 

M. J. Carlucci, M. Ciancia, M. C. Matulewicz, A. S. Cerezo, and E. B. Damonte, Antiherpetic activity and mode of action of natural carrageenans of diverse structural types, Antiviral Res., 43 (1999) 93-102. 

Araucaria angustifolia (Araucariaceae) is a Brazihan medicinal plant traditionally used for the treatment of various diseases including dry skin, wounds, shingles, and sexually transmitted diseases. The ethyl acetate (EA) and n-butanol (NB) fractions showed the best results for antiherpetic activity and further fractionation yielded 22 subfractions. Of these subfractions, 14 were active, and the most potent antiherpetic activity was obtained for the subfraction NBl-4 with a selectivity index (SI) of 57.51. Chemical analysis of NBl-4 subfractions revealed the presence of proanthocyanidins and the known biflavonoids bilobetin (l-4 -0-methylamentoflavone) (3), 11-7-0-... 

TAKECHI, M., TANAKA, Y., TAKEHARA, M., NONAKA, G.-l., NISHIOKA, 1., Structure and antiherpetic activity among the tannins, Phytochemistry, 1985,24,2245-2250. 

Arisawa, M. Fujita, A. Hayashi, T. Ockiai, H. Morita, N. Cytotoxic and Antiherpetic Activity of Phloroglucinol Derivatives from Mallotus japonicus (Euphorbiaceae). Chem. Pharm. Bull. 1990, 38, 1624-1626. 

Lee, J. B., Hayashi, K., Maeda, M., and Hayashi, T. (2004b). Antiherpetic activities of sulfated polysaccharides from green algae. Planta Med. 70,813-817. 

The effects of pH and a complex-forming counter-ion can also be combined to achieve the required separation. The analysis of a mixture of antiherpetically active substances (phosphonoformate and phosphonoacetate) and the admixtures from their synthesis (formate, acetate and phosphate) can serve as an example (Fig. 8). 

The antiviral activity of the oil obtained from Artemisia arborescens L was also studied by Sinico et al. (2005). They studied the influence of vesicle structure and composition on the antiviral activity, against herpes simplex virus type 1 (HSV-1), of the vesicle-incorporated oil, multilamellar vesicles (MLV), and small unilamellar vesicles (SUV) positively charged liposomes prepared by the film method and sonication. The liposomal incorporation of A. arborescens EO enhanced the in vitro antiherpetic activity mainly when vesicles were made with hydrogenated soy phosphatidylcholine. 

Carvone was used as a precursor for the synthesis of the cyclohexene 159, and this was used to make the cyclohexenyl nucleoside analogue 160. The same chiral precursor was also manipulated to give the enantiomers of 159 and 160. Both enantiomers of 160 showed potent antiherpetic activity. Molecular modelling of the binding of both compounds to the active site of HSV-1 thymidine kinase was carried out, and a model for the binding of both enantiomers was proposed.An analogue of carbocyclic 2 -deoxyuridine, conforma-tionally-restricted due to a 6,6 -oxido-link (Vol. 32, p. 278), has now been reported in optically-active form, in the L-series. ... 

Quideau S, Varadinova T, Karagiozova D, Jourdes M, Pardon P, Baudry C, Genova P, Diakov T, Petrova R (2004) Main structural and stereochemical aspects of the antiherpetic activity of nonahydroxyterphenoyl-containing C-glycosidic ellagitannins. Qiem Biodivers 1 247-258... 

Michelini FM, Ramirez JA, Berra A, Galagovsky LR, Alche LE (2004) In vitro and in vivo antiherpetic activity of three new synthetic brassinosteroid analogues. Steroids 69 713—720 Castilla V, Ramirez J, Coto CE (2010) Plant and animal steroids a new hope to search for antiviral agents. Curr Med Chem 17 1858—1873... 

J.B. Lee, K. Hayashi, M. Maeda, and T. Hayashi, Antiherpetic activity of sulfated polysaccharide from green algae, Planta Med., 70, 813-817, 2004. 

Lyu SY, Rhim JY, Park WB (2005) Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. Arch Pharm Res 28 1293-1301 Marchetti M, Pisani S, Pietropaolo V et al (1996) Antiviral effect of a polysaccharide from Sclerotium glucanicum towards herpes simplex virus type 1 infection. Planta Med 62 303-307... 

Pujol, CA Errea, MI Matulewicz, MC Damonte, EB. Antiherpetic Activity of SI, an Algal Derived Sulphated Galactan. Phytotherapy Research, 1996,10,410-413. 

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