Antigenic effects

McMahon B.M., Stewart J.A., Bitner M.D., Fauq a., McCormick D.)., Rich elson E. Peptide nucleic acids specifically cause antigene effects in vivo by systemic injection. Life Sci. 2002 71 325-337. 

Immunization antigen Mucosally applied antigen Effects/target organs... 

PCBs are small molecules and they do not have antigenic effects. They are defined as haptens, i.e. they are molecules that need to be linked with a transport protein in order to generate an immunogenic response. 

Taking into account that (2) is mitogenic but still has no antigenic effect, we suggest that induction of tolerance by this polymer is due to formation of DNP-specific suppressor cells. This would explain why DIVEMA is immune stimulating (induces proliferation of lymphocytes) without causing production of antibodies (2) induces active suppression and thus leads to the apparent lack of immunogenicity. 

Distortionless enhancement by polarization transfer = Epstein-Barr virus early antigen = Effective concentration 50... 

The interaction that results in neutralisation of the thrombolytics is established and clinically important. One author says that clinically, therapy is not repeated within a year as it would not work. Given that it has been suggested that the effects may be very persistent, it would seem prudent, if a second use is needed, to use a thrombolytic with less antigenic effects such as alteplase. The British National Formulary says that streptokinase should not be used again beyond 4 days of the first use of either streptokinase or anistreplase. In addition, the manufacturer recommends avoidance of streptokinase in patients who have had recent streptococcal infections that have produced high anti-streptokinase titres, such as acute rheumatic fever or acute glomerulonephritis. ... 

If the biosensor is to be used for invasive monitoring in clinical situations, the probe must be tiny and biocompatible, having no toxic or antigenic effects. 

Vitamin deficiency Animal Antigen Effect on antibody formation Reference... 

The requirements for vitreous replacement materials include (1) transparency (2) similar refi-active index and density to the vitreous (3) no germs and nontoxic (4) no antigen effect (5) nonflammable (6) no enhancement of cell growth (7) stability in the body (8) slow absorption (9) no solubility in water and (10) ability to inject. However, as the vitreous replacement material is just a filler for a short period of time during retinal or lens surgery, it only needs to satisfy conditions (1), (2), (3), (4), (5), and (10). 

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