Antifungal drug discovery

Roemer, T. et al. 2003. Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol. Microbiol. 50, 167-181. 

Phytochemistry has proven to be fertile ground for antifungal drug discovery [42] and promises to continue to do so given the inherent chemical diversity and relevance of the chemical defense mechanisms in plants in response to fungal infections [114]. An overview of the research in this area is presented as much of this work has been reviewed many times. 

Cossum, P. "Preclinical Evaluation of a Liposomal Nystatin Formulation", Abstracts of Papers, The 1995 Antifungal Drug Discovery Summit, Princeton, NJ Strategic Research Institute New York, New York, 1995. 

Dominique Sanglard, Integrated antifungal drug discovery in Candida albicans. Nature Biotechnology, 19 (2001), 212-213. 

Jacob MR, Walker LA. Natural products and antifungal drug discovery. In Ernst EJ, Rogers P, eds. Methods in Molecular Medicine, vol 118 Antifungal Agents Methods and Protocols. Totowa, NJ Humana Press, 2005 83-109. 

Need for New Antifungal Drugs Discovery of Antifungal Natural Products... 

Sheng C, Zhang W (2011) New lead structures in antifungal drug discovery. Curr Med Chem 18 733-766... 

Keywords Multicomponent reactions Heterocyles Drug discovery Antimicrobial Anticancer Antioxidant Antibacterial Antifungal Antimycobacterial Dicarbonyl based MCRs Isocyanide based MCRs Knoevenagel based MCR... 

There are many examples in the literature for applications of LC-NMR in the pharmaceutical industry. In the area of natural products, LC-NMR has been applied to screen plant constituents from crude extracts [54,57,67,68] and to analyze plant and marine alkaloids [69-72], flavonoids [73], sesquiterpene lactones [74,75], saponins [58,76], vitamin E homologues [77], and antifungal and bacterial constituents [56,78,79] as examples. In the field of drug metabolism, LC-NMR has been extensively applied for the identihcation of metabolites [42, 80-88] and even polar [89] or unstable metabolites [43]. And hnally, LC-NMR has been used for areas such degradation products [90-93], drug impurities [94-102], drug discovery [103,104], and food analysis [105-107]. 

Me Alpine JB, et al. Microbial genomics as a guide to drug discovery and structural elucidation ECO-02301, a novel antifungal agent, as an example. J. Nat. Prod. 2005 68 493 96. 

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