Antidepressants neuroleptic

Antidepressants, Neuroleptics Acetic anhydride with pyridine El Bickeboeller-Friedrich... 

BickeboeUer-Friedrich J, Maurer H. 2001. Screening for the detection of new antidepressants, neuroleptics, hypnotics... 

In SUMMARY, it would appear that a detailed knowledge of the pharmacokinetics of the main groups of psychotropic drugs is only of very limited clinical use. This is due to limitations in the methods for the detection of some drugs (e.g. the neuroleptics), the presence of active metabolites which make an important contribution to the therapeutic effect, particularly after chronic administration (e.g. many antidepressants, neuroleptics and anxiolytics), and the lack of a direct correlation between the plasma concentration of the drug and its therapeutic effect. Perhaps the only real advances will be made in this area with the development of brain imaging techniques whereby the concentrations of the active drug in the... 

Central Motor restlessness, progressing to maniacal agitation, psychic disturbances, disorientation, and hallucinations. Elderly subjects are more sensitive to such central effects, in this context, the diversity of drugs producing atropine-like side effects should be borne in mind e.g., tricyclic antidepressants, neuroleptics, antihistamines, antiarrhythmics, antiparkinsonian agents. 

This is indeed the case. In addition to gamma-aminobutyric acid (GABA), opiate and cholecystokinin receptor activities, the benzodiazepine scaffold is also found in muscle relaxants, antidepressants, neuroleptics, hypnotics, NK-1 receptor and vasopressin receptor antagonists, integrin antagonists, farnesyl transferase and phosphodiesterase inhibitors, potassium channel modulators, and others. 

P-Adrenoreceptor blockers Antidepressants Neuroleptics An tiarrhy thmic drugs Miscellaneous... 

CNS Sedative-hypnotic Anticonvulsant Muscle relaxant Anesthetic Analgesic (narcotic and non-narcotic) Anxiolytic Dementia/cognition Antidepressant Neuroleptic/antipsychotic... 

Clozapine has a proconvulsant effect. Factors that increase the likelihood of seizures include high doses of clozapine, rapid dose titration, the concurrent use of other epileptogenic agents (such as antidepressants, neuroleptic drugs, and mood stabilizers) and a previous history of neurological abnormalities (46). 

Absorption of lithium from guinea pig jejunum has been studied using an isolated mucosal preparation from which the underlying mus-cularis mucosae has been stripped (164). Absorption was shown to occur via a paracellular route and was unaffected by metabolic inhibitors or antidepressant, neuroleptic, or antiinflammatory drugs (165-167). These findings confirmed earlier work using everted sacs prepared from rat intestine (168, 169). The passive nature of lithium uptake into both kidney slices and isolated guinea pig intestinal epithelial cells has also been reported (170, 171). 

Anon. Extrapyramidal reactions to SSRI antidepressant + neuroleptic combinations. Preserve Int (2004) 13, 57. 

Abusive drugs + 700-1200 morphine and derivatives, benzodiazepines, cocaine, hallucinogens, tetrahydro-cannabinols, tricyclic antidepressants, neuroleptics... 

---