Antidepressants analgesic activity

A variety of thiochromans possess biological activity. For example, 7-sulfamoylthiochroman 1,1-dioxides are effective diuretics 130-134 thiochroman-6-acetic acids possess antiinflammatory, antipyretic, and analgesic activity 135-136 phenethylamines from the Mannich reaction on thiochroman-4-ones are a-sympatliolytic137 and antidepressant 138 4-substituted aminothiochromans are active as antihypertensives, as antidepressants, and as agents against angina pains 139-142 3,3-dibromo-6-halothiochroman-4-one S-oxides exhibit antitumor characteristics 143 substituted 4-phenylthiochroman-4-ols have been prepared... 

Wardakhan WW, Abdel-Salam OME, Elmegeed GA (2008) Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives. Acta Pharm 58 1-14... 

DilAienylpropylamines emd Miscellaneous thiophthalanes studied for analgesic activity,-most active. It was approximately equal to morphine (mice, hot-plate, tail-pinch and Mlsen tests), produced a Straub-tail reaction and was antagonized by nalorphine. Similar thiophthalanes with a propylamlno side chain had been previously studied as antidepressants, but were not analgesics and did not produce a Straub-tall. 

This peripheral activity may be a rational basis for the use of systemic local anaesthetics in neuropathic states since ectopic activity in damaged nerves has been shown to be highly sensitive to systemic sodium channel blockers. This too is probably part of the basis for the analgesic effects of established effective anti-convulsants that block sodium channels such as carbamazepine, although central actions are important and may even predominate. The precise actions of excitability blockers therefore remains hazy as does any clear basis for the effectiveness of antidepressants and other adrenergic agents in the treatment of neuropathic pain as both central and peripheral actions, including sympathetic effects are possible. 

A variety of drugs with antiepileptic, antispastic, or antidepressant activity are used to manage cranial neuralgias. These compounds are usually more useful than agents with general analgesic properties. 

Drugs and chemicals are known to cause activated interaction. The depressant action of opioid drugs is enhanced by drugs acting on the central nervous system (CNS) such as alcohol, anesthetics, anxiolytics, hypnotics, tricyclic antidepressants, and antipsychotics. Concomitant administration of opioid analgesics and monoamine oxidase inhibitors (MAOIs) should be avoided, or extra care should be taken if such a therapy is inevitable. Fatal reactions are reported when treated along with selegiline. Interactions also are reported with cyclizine, cimetidine, mexiletine, cisapride, metoclopramide, or domperidone. 

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