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Anticoagulants administration

Heparin is usually administered for a period ranging from 7 to 10 days. Frequently, during file last half of litis period of heparin liierapy, oral anticoagulation will be commenced with warfann. The time during which oral anticoagulation administration should be continued may be three months or longer after clinical evidence that file venous thrombosis has subsided and for one year after pulmonary embolism. [Pg.133]

Perkins J. Phenindione sensitivity. Lancet 1962 1 127-30. Report of the Working Party on Anticoagulant Therapy in Coronary Thrombosis to the Medical Research Council. Assessment of short-anticoagulant administration after cardiac infarction. BMJ 1969 l(640) 335-42. [Pg.1734]

In the case of partial venous thrombosis, anticoagulants administration is usually sufficient. However, when confronted with early complete thrombosis, rapid surgical revascularization is required... [Pg.74]

The pharmacological and/or adverse effects of a drug can be reversed by co-administration of drugs which compete for the same receptor. For example, an opioid receptor antagonist naloxone is used to reverse the effects of opiates. Drugs acting at the same site with opposite effects also can affect each other, e.g. the reduction in the anticoagulant effect of warfarin by vitamin K. [Pg.449]

Use of the macrolides increases serum levels of digoxin and increases the effects of anticoagulants. Use of antacids decreases the absorption of most macrolides. The macrolides should not be administered with clindamycin, lincomycin, or chloramphenicol a decrease in the therapeutic activity of the macrolides can occur. Concurrent administration of the macrolides with theophylline may increase serum theophylline levels. [Pg.86]

Concurrent use of the fluoroquinolones with theophylline causes an increase in serum theophylline levels. When used concurrently with cimetidine, the cimetidine may interfere with the elimination of the fluoroquinolones. Use of the fluoroquinolones with an oral anticoagulant may cause an increase in the effects of the oral coagulant. Administration of the fluoroquinolones with antacids, iron salts, or zinc will decrease absorption of the fluoroquinolones. There is a risk of seizures if fluoroquinolones are given with the NSAIDs. There is a risk of severe cardiac arrhythmias when the fluoroquinolones gatifloxacin and moxifloxacin are administered with drains that increase the QT interval (eg, quini-dine, procainamide, amiodarone, and sotalol). [Pg.93]

Sulfinpyrazone may increase die anticoagulant activity of oral anticoagulants. There is an increased risk of hypoglycemia when sulfinpyrazone is administered with tolbutamide. Concurrent administration of sulfinpyrazone widi verapamil may decrease die effectiveness of verapamil. [Pg.191]

Administration of the thrombolytic drugp with aspirin, dipyridamole, or the anticoagulants may increase the risk of bleeding. [Pg.429]

Heparin may be given along with and/or after administration with a thrombolytic drug to prevent another thrombus from forming. However, administration of an anticoagulant increases the risk for bleeding. The patient must be monitored closely for internal and external bleeding. [Pg.431]

When the anabolic steroids are administered with anticoagulants the anticoagulant effect maybe increased. Administration of methyitestosterone with imipramine may cause a paranoid response in some patients The anabolic steroids may increase the hypoglycemic action when administered with thesulfonylureas... [Pg.541]

The administration of cloflbrate to a patient taking warfarin will potentiate the anticoagulant effect of warfarin by displacing It from Its protein binding site (7). This Interaction will cause... [Pg.277]

Doses and contraindications to glycoprotein Ilb/IIIa receptor blockers are described in Table 5-2. Major bleeding and rates of transfusion are increased with administration of a glycoprotein Ilb/IIIa receptor inhibitor in combination with aspirin and an anticoagulant,30 but there is no increased risk of intracranial hemorrhage in the absence of concomitant fibrinolytic treatment. The risk of thrombocytopenia with tirofiban and eptifibatide appears lower than that with abciximab. Bleeding risks appear similar between agents. [Pg.100]

IV administration is needed when rapid anticoagulation is required. A weight-based IV bolus dose followed by a continuous IV infusion is preferred (Table 14-2). [Pg.180]

Heparin, which has an anticoagulation action, may give rise to heparin-induced thrombocytopenia, which is an immune-mediated condition that usually develops 5-10 days after the administration of the drug. When heparin is used, a platelet count should be measured before treatment and if administration is repeated, platelet counts should be monitored regularly. Signs of thrombocytopenia include a reduction in platelet count. It may present with spontaneous haemorrhage and heparin should be stopped. Factor VIII is used in the treatment and prophylaxis of haemorrhage in patients with haemophilia. [Pg.117]


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See also in sourсe #XX -- [ Pg.385 , Pg.387 , Pg.404 ]




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