Anticoagulants interaction

Grau E, Perella M, Pastor E. Simvastatin-oral anticoagulant interaction. Lancet 1996 347(8998) 405-6. 

Sanchez B, Muruzabal MJ, Peralta G, et al. Clarithromycin oral anticoagulants interaction report of five cases. Chn Drug luvest 1997 13 220-2. 

Grau E, Fontcuberta J, Felez J. Erythromycin-oral anticoagulants interaction. Arch Intern Med 1986 146(8) 1639. 

Unwanted side effects and undesirable interactions can occur when herbals are taken with prescription medication. For example, Coumadin, which is an anticoagulant, interacts with ginkgo, an herb that inhibits platelets, resulting in increased bleeding and stroke. 

Sdnchez B, Muruzat l MJ, Peralta G, Santiago G, Castilla A, Aguilera JP, Aijona R Clarithromycin-oral anticoagulants interaction R ort of five cases. Clin Drug Invest (1997) 13, 220-2. 

Heparin is an important anticoagulant. It binds with factors IX and XI, but its most important interaction is with plasma antithrombin III (discussed in Chapter 51). Heparin can also bind specifically to lipoprotein lipase present in capillary walls, causing a release of this enzyme into the circulation. 

The administration of cloflbrate to a patient taking warfarin will potentiate the anticoagulant effect of warfarin by displacing It from Its protein binding site (7). This Interaction will cause... 

This was largely influenced by the high-dose UFH group in 1ST (OR 1.38, 95% Cl 1.05-1.82). An interaction by UFH dose (p = 0.01) on recurrent stroke risk with combination UFH-aspirin therapy compared to aspirin monotherapy was observed, with a trend toward increased risk of recurrent stroke with high-dose UFH + aspirin (OR 1.22, 95% Cl 0.92-1.62) and a trend toward reduced risk with low-dose UFH + aspirin (OR 0.75, 95% Cl 0.56-1.03), equivalent to 10 fewer (95% Cl 0-20 fewer) recurrent strokes per 1000 patients treated. They found a small, but significant beneht of LMWH over aspirin in the prevention of symptomatic DVT, equivalent to 10 (95% Cl 0-30) fewer DVTs per 1000 patients treated. Compared with aspirin, anticoagulants were associated with nonsignificantly fewer symptomatic PEs (OR 0.85, 95% Cl 0.55-1.32). There were fewer PEs with the combination of UEH and aspirin (OR 0.58, 95% Cl 0.34—1.00), equivalent to 5 fewer (Cl 0-10) PEs per 1000 patients treated. However, the overall incidence of symptomatic DVT and PE was low (1.1% and 0.7%). 

Screen the patient s pharmacy profile for potential drug-drug interactions with anticoagulation therapy... 

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