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Anticoagulant drugs pharmacology

There is thus obtained bishydroxycoumarin (3). Subsequent pharmacologic and clinical work revealed this compound to be an effective anticoagulant drug in humans. It is of note that none of the synthetic anticoagulants shows in vitro activity. Rather, these compounds owe their effect to inhibition of synthesis by the liver of one of the co-factors necessary for coagulation. [Pg.331]

Editor s Note Tile following references have been selected to provide the interested reader wiLli more detail on the pharmacologic complexities of anticoagulants Tile article by Edwin W. Salzman, M.D. is a short, but excellent summary of the status of antithrombotic drugs as of early 1992. The article on heparin by Jack Hirsh, MD. and the article on warfarin by the same author proride important fundamental background information on the pharmacokinetics and pharmacodynamics of the most widely used anticoagulant drugs, Brandjes. D.P.M., et al. Acenocoumarol and Heparin Compared with Acenocoumarol. Alone in the Initial Treatment of Proximal-Vein Thrombosis," N. Eng. J. Med., 1485 (November 19, 1992). [Pg.134]

The pharmacological and/or adverse effects of a drug can be reversed by co-administration of drugs which compete for the same receptor. For example, an opioid receptor antagonist naloxone is used to reverse the effects of opiates. Drugs acting at the same site with opposite effects also can affect each other, e.g. the reduction in the anticoagulant effect of warfarin by vitamin K. [Pg.449]

Predictable effects that derive from the known pharmacological drug properties. Examples are masculin-ization of the female fetus by androgenic hormones brain hemorrhage due to oral anticoagulants bradycardia due to p-blockers. [Pg.74]

Most literature reports of pharmacodynamic botanical-drug interaction involve the anticoagulant warfarin, likely because it has therapeutic end points such as the INR and PT, which are routinely closely monitored. In addition, most botanicals possess anticoagulant and/or antiplatelet activities, and their combined use with warfarin provides a good example of pharmacodynamic interaction with additive pharmacological effect. [Pg.34]


See other pages where Anticoagulant drugs pharmacology is mentioned: [Pg.140]    [Pg.757]    [Pg.764]    [Pg.616]    [Pg.193]    [Pg.174]    [Pg.587]    [Pg.139]    [Pg.139]    [Pg.760]    [Pg.101]    [Pg.449]    [Pg.134]    [Pg.144]    [Pg.134]    [Pg.238]    [Pg.30]    [Pg.197]    [Pg.198]    [Pg.20]    [Pg.29]    [Pg.448]    [Pg.131]    [Pg.139]    [Pg.260]    [Pg.261]    [Pg.255]    [Pg.34]    [Pg.192]    [Pg.260]    [Pg.92]    [Pg.200]    [Pg.199]    [Pg.213]    [Pg.313]    [Pg.347]    [Pg.10]    [Pg.11]    [Pg.44]    [Pg.48]    [Pg.87]    [Pg.31]    [Pg.201]    [Pg.1]    [Pg.20]   
See also in sourсe #XX -- [ Pg.128 ]




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