Anticholinergics post-exposure

Standard post-exposure treatments include eoneurrent administration of anticholinergics, such as the musearinie cholinergic blocker atropine sulfate, and AChE reactivators, such as obidoxime and pyridine-2-aldoxime methochloride (also known as 2-PAM). Oximes cannot reactivate OP-inhibited AChE that has already aged . Therefore, traditional oxime treatment is considered to be less effective for those agents such as soman, for which aging is rapid (Worek et al, 2005). 

The inhibition of AChE leads to the accumulation of the neurotransmitter ACh in synapses of the central and peripheral nervous systems and over-stimulation of post-synaptic cholinergic receptors. Exposure to even small amounts of an organophosphorus compound can be fatal as the poison causes seizures, convulsions and lesions of the central nervous system. The current standard treatment for poisoning usually consists of combined administration of anticholinergic drugs (preferably atropine) and AChE reactivators (called oximes). 

---