Anticholinergic symptom

Disopyramide Anticholinergic symptoms (dry mouth, urinary retention, constipation, blurred vision), nausea, anorexia, TdP, HF, aggravation of underlying conduction disturbances and/or ventricular arrhylhmias, hypoglycemia... 

Ness J, Floth A, Barnett MJ et al. (2006) Anticholinergic medications in community-dwelling older veterans prevalence of anticholinergic symptoms, symptom burden, and adverse drug events. Am J Geriatr Pharmacother 4(1) 42-51... 

Anticholinergics (e.g. cyclizine and cinnarizine) are useful and efficacious but can cause drowsiness, which limits long-term use in the elderly. They also cause classic anticholinergic symptoms of dry mouth, blurred vision, constipation, etc., which can be troublesome in the elderly in general. In addition, constipation is commonly associated with Parkinson s disease, and unsteadiness... 

Cimetidine may increase plasma concentrations of TCAs and cause anticholinergic symptoms... 

Fluoxetine, paroxetine, bupropion, duloxetine, and other CYP450 2D6 inhibitors may increase TCA concentrations Cimetidine may increase plasma concentrations of TCAs and cause anticholinergic symptoms Phenothiazines or haloperidol may raise TCA blood concentrations May alter effects of antihypertensive drugs may inhibit hypotensive effects of clonidine Use of TCAs with sympathomimetic agents may increase sympathetic activity Methylphenidate may inhibit metabolism of TCAs... 

The CBs used as pesticides are N-substituted esters of carbamic acid. CBs developed in the 1950s as insect repellents were found to have insecticidal activity, leading to the development of the napthyl CBs with high anti-ChE activity and selective toxicity against insects. One example is carbaryl it is widely used because of its low toxicity to mammals and its degradability. Aldicarb, a plant systemic, is more toxic than carbaryl. A few years ago aldicarb was associated with a July 4th holiday incident when West Coast residents complained of anticholinergic symptoms after eating aldicarb-contaminated watermelon. 

The cardiovascular, CNS, and anticholinergic symptoms of phenothiazine toxicity are similar to, but generally much less severe than, those for the tricyclic antidepressants. Phe-nothiazines are relatively safe, and few deaths have occurred when toxic doses have been ingested alone. Much more severe toxicity occurs when phenothiazines are co-ingested with tricyclic antidepressant drugs or other CNS depressant drugs, such as ethanol, opioids, barbiturates, or benzodiazepines. 

Anticholinergic symptoms, such as dry mouth, mydriasis, urinary retention, and hypoactive bowel sounds, develop within 1 to 6 hours... 

Disopyramide Anticholinergic symptoms, Gl, torsade de pointes, heart failure, aggravation of... 

The manifestations with buclizine overdosage may include either those of CNS depression (sedation, reduced mental alertness, apnea, and cardiovascular collapse) or of CNS stimulation (insomnia, hallucinations, tremors, or convulsions). Anticholinergic symptoms, such as dry mouth, flushed skin, fixed and dilated pupils, and G1 symptoms, are common, especially in children. 

This agent should not be used in overdose of a tricyclic antidepressant, though it would reverse many of the anticholinergic symptoms that occur... 

Tricyclic antidepressant overdose includes cardiotoxicity, convulsions, and symptoms of muscarinic receptor blockade. The antidote for the quinidine-Uke cardiotoxicity of tricyclic antidepressants is sodium bicarbonate. Although physostigmine does effectively reverse anticholinergic symptoms, it can aggravate depression of cardiac conduction and can cause seizures. The answer is (J). 

The adverse effects for fluvoxamine include symptoms of drowsiness, nausea or vomiting, abdominal pain, tremors, sinus bradycardia, and mild anticholinergic symptoms. Toxic doses could produce seizures and severe bradycardia. 

Ibotenic acid-induced or muscimol-induced anticholinergic symptoms may improve with physostigmine (see p 489). 

B. Specific drugs and antidotes. There are no specific antidotes. Flumazenll (see p 446) Is a specific antagonist of benzodiazepine receptors, and would not be expected to cross-react with skeletal muscle relaxants or other sedative agents. While physostigmine may reverse anticholinergic symptoms associated with cyclobenzaprine and orphenadrine overdose. It Is not generally needed and may potentially cause seizures. 

Marquez et al. [48] reported a single case of a yotmg man who drank 0.5 L of water that had been used for lupin seeds debittering process. He suffered from sudden weakness, palpitations, extrasystoles, and different anticholinergic symptoms. 

---