Anticholinergic effects mirtazapine

Mirtazapine is associated with modest anticholinergic side effects, including dry mouth and constipation. Anticholinergic side effects and their management are discussed in the Tricyclic and Heterocyclic Antidepressants section later in this chapter. [Pg.40]

Mirtazapine [Remeron] Exact mechanism unclear may increase norepinephrine and serotonin activity by blocking inhibitory presynaptic autoreceptors Low incidence of sedative, anticholinergic, and cardiovascular side effects May cause agitation, anxiety, other mood changes... [Pg.83]

Among the TCAs, desipramine and nortriptyline are the most recommended, since they have few anticholinergic side-effects. Sertraline has been studied in a placebo-controlled randomized trial and is considered one of the safest drugs for elderly patients post myocardial infarction, since it has no negative impact on cardiac measures. A number of placebo-controlled studies of post-stroke depression have shown efficacy for citalopram at doses of 10 mg and for nortriptyline (but not for fluoxetine). Venlafaxine may also be considered however, it should be used with caution since in 3-5% of patients it increases blood pressure. Mirtazapine may be used in patients with insomnia and decreased appetite due to its sedative side-effects and its promotion of increased appetite. ... [Pg.215]

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