Antibody-mediated damage, autoimmune

E. Abnormal Immune Responses Abnormal immune responses include hypersensitivity, autoimmunity, and inununodeficiency states. Immediate hypersensitivity is usually antibody-mediated and includes anaphylaxis and hemolytic disease of the newborn delayed hyptersensitiv-ity, associated with extensive tissue damage, is cell-mediated. Autoinununity arises from self-reactive lymphocytes that react to one s own molecules, or self-antigens. Examples of autoimmune diseases that are amenable to dmg treatment include rheumatoid arthritis and systemic lupus erythematosus. Immunodeficiency states may be genetically acquired (eg, Di George s syndrome) or result from extrinsic factors (eg, AIDS). 

R6. Reichlin, M., Cellular dysfunction induced by penetration of autoantibodies into living cells Cellular damage and dysfunction mediated by antibodies to dsDNA and ribosomal P proteins. J. Autoimmun. 11, 557-561 (1998). 

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