Antibody complementarity determining regions

Saragovi, H.U. Fritzpatrick, D. Raktabutr, A. Nakanishi, H. Kahn, M. Greene, M.l. Design and synthesis of a mimetic from an antibody complementarity determining region. Science 1991, 253, 792-795. 

H. U. Saragovi, D. Fitzpatrick, A. Raktabutr, H. Nakanishi, M. Kahn, and M. I. Greene, Science, 25i, 792 (1991). Design and Synthesis of a Mimetic from an Antibody Complementarity-Determining Region. 

Cacia, J., Keck, R., Presta L. G., and Frenz, J., Isomerization of an aspartic acid residue in the complementarity-determining regions of a recombinant antibody to human IgE identification and effect on binding affinity, Biochemistry, 35, 1897, 1996. 

Bevacizumab is produced using CHO expression in a nutrient medium with gentamicin antibiotic. It has a molecular weight of 149 kDa. The antibody is humanized, with human framework and murine complementarity-determining regions. 

Jones, P.T., Dear, P.H., Foote, J., et al. (1986). Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature, 321, 522-525. 

Tan P, Mitchell DA, Buss TN, Holmes MA, et al. 2002. Super humanized antibodies Reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences Application to an anti-CD28. J Immunol. 169 1119-1125. 

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