Antibodies genetically engineered

The advent of genetic engineering and monoclonal antibody technology underpinned the establishment of literally hundreds of start-up biopharmaceutical (biotechnology) companies in... 

Lerner, M.B., et al., Hybrids of a genetically engineered antibody and a carbon nanotube transistor for detection of prostate cancer biomarkers. ACS Nano, 2012. 6(6) p. 5143-5149. 

As discussed previously, murine antibodies have limitations. The next phase of development is to make these murine MAbs more like human antibodies, by using genetic engineering techniques. A recent approach is to humanize the antibodies to reduce HAMA and improve the avidity of the MAbs (avidity... 

Whole IgG antibodies with a molecular weight of 150 kDa, are often unable to penetrate tumour tissue as efficiently as smaller molecules [18]. Therefore, smaller antibody fragments and genetically-engineered antibody derivatives have been investigated as drug carriers (see Figure 11.5). These carrier molecules will be discussed in Section 11.8.1. 

Table 9.1. Major blood products that find therapeutic application. While all of these products are still sourced from human blood donations, a number of the protein-based products are now also produced by genetic engineering. Antibody preparations are considered in the next chapter...

ANTIBODIES, VACCINES AND ADJUVANTS 441 The impact of genetic engineering on vaccine technology... 

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