Antibodies general structure

Microtubules in the cytoskeleton and mitotic apparatus are also in a state of dynamic equilibrium and flux with unpolymerized tubulin, and tubulin appears to be an excellent example of the proteins which Pauling (1953) postulated to exist as globular protomers or as insoluble, fibrous, supramolecular structures akin to unpolymerized and polymeric hemoglobin S. The current view of the microtubule cytoskeleton in nondividing celb comes from the development of tubulin-specific antibodies for indirect immunofluorescent localization of microtubules (Fuller et al., 1975 Weber et al., 1975). The general structural features of such cyto-... 

Early investigations supporting the concept that exposed haptenic determinants are immunodominant were carried out by Sela and his collaborators, who prepared antibodies against a number of synthetic polypeptides of high molecular weight with the general structure illustrated in Fig. 2.5. The backbone of the polymer consists of poly-L-lysine. The... 

An experiment to estimate the depth of the antibody combining site was carried out by Hsia and Piette (93). They synthesized compounds with the general structure H —d—SL where H represents the 2,4-di-nitrophenyl hapten, d is a spacer which can be varied in size, and SL is the spin-labeled group. 

Figure 9 Structure of the immunogen hapten used to generate antibodies for a type I pyrethroid class-selective assay. Pyrethroids lacking an a-cyano group are generally termed type I. This hapten exposed the features most common to type I pyrethroids, the phenoxybenzyl group, the cyclopropyl group and the lack of a cyano group, resulting in antibodies that recognized permethrin, phenothrin, resmethrin and bioresmethrin, but not cypermethrin...

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