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Antibiotics target bacteria susceptibility

Abstract The use of antibiotic therapy in aquaculture inevitably leads to the emergence of resistance in the target bacteria and a reduction of the efficacy of this method of disease control. It is argued that a better understanding of the aetiology of aquatic animal diseases and the potential of antibiotics to control disease losses is essential if we are to achieve a more prudent use of this therapy. The ability to detect resistance in target bacteria will be central if we are to use these agents wisely the methods available to measure bacterial susceptibility are critically analysed. [Pg.161]

In both bacteria and eucarya the susceptibility to certain ribosome-targeted inhibitors correlates with specific primary structural features of rR24A, or with features of the ribosomal domain that acts as the antibiotic binding sites. Firstly, resistance to specific ribosome-directed drugs is conferred by single-base changes within phylogenetically... [Pg.420]

Unfortunately, many bacteria acquire resistance to one or more of the antibiotics to which they were formerly susceptible. Since most antibacterial agents interact with a specific protein or cellular component, modification of the target is a common means by which resistance can be conferred. Pharmaceutical companies are actually developing new antimicrobial agents against resistant bacteria. [Pg.113]

Inhibition of bacterial growth that continues after antibiotic blood concentrations have fallen to low levels is called the postantibiotic effect (PAE). The mechanisms of PAE are unclear but may reflect the lag time required by bacteria to synthesize new enzymes and cellular components, the possible persistence of antibiotic at the target site, or an enhanced susceptibility of bacteria to phagocytic and other defense mechanisms. PAE may be another factor contributory to the clinical effectiveness of high-dose, once-daily administration of aminoglycosides. [Pg.449]

Any maneuver that increases the population of H. pylori undergoing division will make the bacteria relatively more susceptible to either amoxicillin or clarithromycin or both (because they have biochemically distinct targets). Remembering the survival and growth data previously shown, the organism survives over a much wider pH range than that found for growth. So, if antibiotic... [Pg.501]


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Antibiotics susceptibility

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