Antibiotics anthracy cline

Q65 Daunorubicin should be diluted v/ith infusion fluid to a concentration of Img/mL and given over 20 minutes. Daunorubicin is an anthracy-cline antibiotic that is highly irritant to tissues. 

Various drugs, for example, diazepam and indomethacin, doxorubicin, anthracy-cline antibiotics, and polynucleotides, were effectively solubilized in polymeric micelles. Also polymeric micelles can carry various reporter (contrast) groups and... 

In addition lipid peroxidation can result from action of active oxygen species. This leads to destruction of metabolically necessary lipid molecules and damage to the structural integrity of cellular membranes. Damage from oxidative stress can occur with excessive production of active oxygen species, inadequate protection against such species, or both. Examples of toxicity from active oxygen species include the pancreatic beta-cell destruction by alloxan, the neurotoxicity of 6-hydroxydopamine, the cardiotoxicity of the anthracy-cline antibiotics, and the pulmonary toxicity of the herbicide paraquat. 

Batrakova EV, Dorodnych TY, Klinskii EY, et al. Anthracy-cline antibiotics non-covalently incorporated into the block copolymer micelles in vivo evaluation of anti-cancer activity. Br J Cancer 1996 74 1545-1552. 

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