Anti-interference systems, enzymatic

Such interferences can be compensated by using difference measurements, which usually require a reference transducer. An elegant alternative is the use of enzymatic anti-interference systems containing enzymes in front of the sensor that catalyze the conversion of the disturbing compounds to inert products. Such systems have been developed in conjunction with analytical enzyme reactors as well as enzyme electrodes. 

Anti-inflammatory activity was studied on two labdane derivatives isolated from S. javalambrensis [122-124], that also contains other known diterpenoids [98,99,125]. These two products, ent-13-epi-12a-acetoxy-manoyloxide (76) and e t-8a-hydroxy-labda-13(16), 14-diene (98) were evaluated for anti-inflammatory action in vitro in the concentration range 10 7 M to 10 4 M and were compared with aspirin, sodium salicylate and indomethacine neither compound affected superoxide generation or scavenging and nor did inhibit non-enzymatic lipid peroxidation. These two natural products interact with the eicosanoid system, perhaps at the phospholipase level, but do not interfere with the other tested leukocyte functions or with reactive oxygen species, and are essentially non-toxic to... 

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