Anti-inflammatory effect pregnancy

Topical metronidazole is effective in the treatment of rosacea. The mechanism of action is unknown, but it may relate to the inhibitory effects of metronidazole on Demodex brevis alternately, the drug may act as an anti-inflammatory agent by direct effect on neutrophil cellular function. Oral metronidazole has been shown to be a carcinogen in susceptible rodent species, and topical use during pregnancy and by nursing mothers and children is therefore not recommended. 

Documented effects Mature fruits are used as a bactericide, anti-inflammatory, to normalize intestine and stomach function, as a source of vitamins, and as a tonic. The bark is used as a diaphoretic, antipyretic, and diuretic. Leaves are used to treat diarrhea and as a source of vitamins. Flowers are used as an anti-inflammatory. Preparations from this species are counter-indicated during pregnancy (Maznev 2004). An extract of the seeds had antibacterial activity against 5 different species, including methicillin-resistant Staphylococcus aureus, and had strong anti-oxidant activity (Kumarasamy et al. 2002, 2007). 

Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med 2000 160 6KC619. 

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