Anti-inflammatory drugs analgesic action

The exact mechanism of action of the drug is not yet established, although inhibition of prostaglandin synthesis most probably contributes heavily to its anti-inflammatory activity. It has been observed adequately that in such patients having rheumatoid arthritis different types of manifestations of its anti-inflammatory and analgesic actions do occur, but there exists little distinct proof of alteration of the progressive course of the prevailing disease. 

Emorfazone (3) exhibits activities equal to or even more potent than those of basic analgesic anti-inflammatory drugs [25, 32, 35, 36], with no inhibiting action on prostaglandin biosynthesis [37,38]. Inhibition of vascular permeability [39] and of bradykinin release [37] was observed with (3). It has been found that the anti-inflammatory action of (3) may be due in part to pituitary-adrenocortical stimulation [40]. 

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID). It exhibits anti-inflammatory, analgesic and antipyretic activities. The mechanism of action is not completely understood but may be related to prostaglandin synthetase inhibition. 

The separation of nonsteroidal anti-inflammatory drugs (NSAIDs) has recently attracted considerable interest. Nonsteroidal anti-inflammatory drugs are agents that, in addition to having anti-inflammatory action, also have analgesic, antipyretic, and platelet-inhibitory properties. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. 

Like paracetamol, aspirin is an analgesic and antipyretic drug which is commonly available for sale over the counter at many shops and supermarkets, as well as pharmacies. However, it also has a third action, to reduce inflammation—it is an anti-inflammatory drug. It belongs to a group of drugs called non-steroidal anti-inflammatory drugs or NSAIDs. 

The antipyretic analgesics, with the non-steroidal anti-inflammatory drugs (NSAIDs), share a common mechanism of action, namely the inhibition of prostaglandin synthesis from arachidonic acid and their release. More precisely their mode of action is thought to result from inhibition of both the constitutive and the... 

Non-steroidal anti-inflammatory drugs (NSAIDs) form a heterogeneous group of organic acids (Table 1) that have analgesic, antipyretic, anti-inflammatory, and platelet inhibitory actions. 

McCormack K 1994 The spinal actions of nonsteroidal antiinflammatory drugs and the dissociation between their anti-inflammatory and analgesic effects. Drugs Supplement 5 2 45... 

First statement Aspirin and ibuprofen are non-steroidal anti-inflammatory drugs (NSAIDs) and theoretically the best OTC analgesics for dysmenorrhoea. Second statement NSAIDs act by promoting the action of the enzyme cyclooxygenase, thus preventing the formation of prostaglandin endoperoxides from arachidonic acid produced when tissue is damaged. 

The differences in the actions of these drugs involve their tissue specificities. Aspirin and ibuprofen act on a broad range of tissues. Acetaminophen inhibits prostaglandin synthesis more specifically in the cells of the nervous system and is a much less effective inhibitor of this in other tissues. This selectivity gives acetaminophen its analgesic and antipyretic effects without acetaminophen s acting as an anti-inflammatory drug. 

Aspirin is one of the most widely used drugs in modem society. It is most frequently used to treat mild to moderate pain or to reduce fever. Because of its anti-inflammatory action, aspirin is prescribed to individuals who suffer from joint inflammation conditions such as rheumatoid arthritis and osteoarthritis. In addition to its antipyretic, anti-inflammatory, and analgesic properties, aspirin is also prescribed to patients at high risk for heart attack... 

It is an anti-inflammatory drug that possesses anti-pyretic and analgesic actions. It is indicated... 

Extracts of A. carmichaelUhave shown cardiotonic activity, including inotropic and chronotropic activities, leading to hypotension and/or hypertension. Analgesic and anesthetic activities have been reported. Hyoscine potentiates the action of aconitine. Aconitine and related compounds exhibit anti-inflammatory and analgesic properties in experimental animals. lateral rootlets of A. carmichaelii (considered a separate drug in Chinese tradition), has been shown to raise the heart rate in sinus arrhjdhmia patients. ... 

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