Anti-HIV flavonoids

Wu, J.-H. et al., Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from the genus Desmos, Bioorg. Med. Chem. Lett., 13, 1813, 2003. 

Shahat, A. A., S.I. Ismail, F. N. Hammouda, and S.A. Azzam. 1998. Anti-HIV activity of flavonoids and proanthocyanidins from Crataegus sinalica. Phytomedicine 5 133-136. 

With nearly 20 years of experience on plant-derived natural products, NPRL has identified numerous active anti-HIV compounds including polycyclic diones, saponins, alkaloids, triterpenes, polyphenols, flavonoids and coumarins. Triterpenes have diverse structures and pharmacological activities. 

Huniulus lupulus (hop) contains a variety of sesquiterpe-noids, diterpenoids, and triterpenoids, phytoestrogens, and the flavonoid xanthohumol, which has some in vitro anti-HIV activity (1). Apart from their use in brewing beer, hops have been used for sedative purposes, but evidence of efficacy is poor. 

Fig. 22 Sophoflavescenol (110), flavonoids, and their anti-HIV activity from roots of Sophora flavescens...

Reutrakul, V. Ningnuek, N. Pohmakotr, M. Yoosook, C. Napaswad, C. Kasisit, J. Santisuk, T. Tuchinda, P., Anti HIV-1 flavonoid glycosides from Ochna integerrima, PlantaMed., 2007, 73, 683-688. 

L., family Hypericaceae. Hypericum contains flavonoids, xanthones, naphthodianthrones such as hypericin and pseudohypericin and phloroglucinols, e.g. hyperforin. Hypericin has anti-HIV activity and is responsible for the photosensitivity reaction which has been documented for St. John s Wort in cattle and... 

Alves CN, Pinheiro JC, Camargo AJ, de Souza AJ, Carvalho RB, da Silva ABF. A quantum chemical and statistical study of flavonoid compounds with anti-HIV activity. J Mol Struct Theochem 1999 491 123-131. 

An organic extract of the leaves of Buchenavia capitata (Vahl) Eichl. showed anti-HIV activity in the screening procedure carried out by the National Cancer Institue in the USA [14]. This activity was traced to the alkaloidal component of the extract. This species had previously been shown to contain a group of flavonoidal alkaloids known as the buchenavianines [15]. 

Wu, J.H., Wang, X.H., Yi, Y.H., Lee, K.H. 2003. Anti-AIDS agents 54. A potent anti-HIV chal-cone and flavonoids from genus Desmos. Bioorganic and Medicinal Chemistry Letters 13(10) 1813-1815. 

Wang, H, Xia, Y, Yang, Z, Natschke, S and Lee, K (1998) Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents. Arfv. Etq). Med. Biol., 439, 191-225. 

FIS is a flavonoid that has attracted significant attention from biological perspectives, considering its inhibitory action against HIV-1 proteinase, a virally encoded protein which is indispensable for maturation and processing of AIDS virus and a viable substrate for anti HIV therapy (Brinkworth, Stoermer Fairlie, 1992). In addition, it has been shown that FIS may act in a similar way as a-tocopherol and could mimic its antioxidant activity in the membranes (van Acker, Schouten, Haenen, van der Vijgh Bast, 2000). 

Okuda et al. have reported that some licorice flavonoids, isolico-flavonol (171), glycycoumarin (172), licochalcones A and B (213 and 214), glycyrrhisoflavone (250) and licopyranocoumarin (256), inhibit the cytopathic activity of HIV (427). Shibata et al. have reported that licochalcone A (213) shows anti-tumor promoting activity in a two-stage mouse skin carcinogenesis experiment (428). Inhibitory activity of... 

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