Anti-HIV drug

Thymidine, 5-methoxypsoralen, and their photoadducts were separated on a C g column (A = 254 nm) using a 35/65 methanol/water mobile phase [550]. The cis-syn and cis-anti monocyclo-adducts were well resolved from the linear adducts and the psoralen dimers. Elution was complete in 45 min. 

---

Mitochondria-associated toxicities, such as pancreatitis, are frequently demonstrated in HlV/HCV-coinfected individuals, and may significantly influence treatment options (de Mendoza and Soriano 2005). Yet, no cell culture or animal models have been developed to predict nucleoside-induced pancreatitis. Nevertheless, an association of HCV replication and mitochondrial DNA depletion in primary human lymphocytes obtained from HIV/HCV-coinfected individuals under concomitant administration of HCV and HIV medications was demonstrated by de Mendoza and coworkers (de Mendoza et al. 2007). They claimed that the use of HCV medication together with certain antiretroviral agents seemed to enhance mitochondrial damage due to a synergistic deleterious interaction between the anti-HCV and anti-HIV drugs. In contrast, an improvement in mitochondrial content with effective... 

Storch CH, Theile D, Lindenmaier H, Haefeh WE, Weiss J (2007) Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein, Biochem Pharmacol 73 1573-1581... 

Princen K, Schols D. HIV chemokine receptor inhibitors as novel anti-HIV drugs. Cytokine Growth Factor Rev 2005 16(6) 659-677. 

The most effective means to accomplish durable suppression of HIV replication is the simultaneous initiation of combinations of effective anti-HIV drugs with which the patient has not been previously treated and that are not cross resistant with antiretroviral agents with which the patient has been treated previously. 

The optical purity of compound (304) is due to the high facial preference of the attack of the olefin on nitronate (303) from the distal side with respect to the substituents at the C-4 and C-6 atoms. Modifications of nucleotides provide a promising approach to the synthesis of new anti-HIV drugs. 

See also Gravimetric techniqugges Acoustic waves, sensors using, 22 269-270 Acoustooptic (AO) modulators, 14 676 Acousto-ultrasonics, in nondestructive evaluation, 17 425-426 Acquired Immunodeficiency Syndrome (AIDS), 3 135 25 500. See also Anti-HIV drug candidates HIV entries Nevirapine entries sulfonamide exposure in, 23 506 Acquisitions, 15 639 Acrawax C, dental wax, 8 296 9-Acridinecarbonylimidazole, as... 

Such dideoxynucleosides as CNT (306) and the potent anti-HIV drug ddC (307) have been obtained (280), respectively, from the butenolide 248 and from its saturated analogue. Thus, conjugate addition of cyanide to 248, followed by reduction of the lactone group, acetylation of HO-1, and coupling with silylated thymine, afforded, after deprotection, compound 306. 

Fuzeon (enfuvirtide) is an anti-HIV drug. It interferes with the entry of HIV into the CD4 cell. It is a synthetic peptide with 36 amino acids, the N terminus is acetylated while the C terminal forms a carboxamide. The peptide binds to the gp41 subunit of the HIV envelope glycoprotein and prevents the HIV from fusing with CD4. 

Progression to AIDS Serum viral mRNA Anti-HIV drugs... 

Antiviral and antitumor properties of nucleoside analogues have given rise to a considerable number of smdies. These compounds are often inhibitors of the enzymes that are involved in the biosynthesis of nucleosides, in DNA replication and transcription phenomena, and in metabolic transformation (e.g., phosphorylation of a nucleoside). For these reasons, fluorinated analogues of nucleosides have been especially studied, and this phenomenon has increased due to the search for anti-HIV drugs. 

---