HIV protease inhibitors as anti-AIDS drugs

Viral envdoppe pnMdn. gpliMI. bixKfing to CD4 rcccptcMrs on helper T-cdb 

Viril mRNA produced under die ccmtrol of regulatory gene products TAT.REV.NEFeto 

Transput to cell membrane Specific cleavi polypqidde precursOTS to generue fimcdonal and structural viral proteins Glycosyhoion mi trimming 

Almost simultaneously, protein and medicinal chemists began to characterise HIV protease by structural studies and inhibitor synthesis, respectively [59,60]. In the aspartate protease family, gene duplication gives rise to two structurally similar domains each having a conserved sequence. Asp- 

Compound Inhibitor of HIV Protease, ICj inM) Antiviral activity IC5o(/rM) TC, (/iM) Reference 

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