Rheum palmatum anthraquinones from

In a study on different anthraquinones from Rheum palmatum, Chen et al. [161] found that emodin, but not physion or chrysophanol, induced apoptosis in HL-60 cells though activation of the caspase 3 cascade. The... 

Figure 24 Separation of anthraquinone glycosides from Cassia angustifolia (B) fmits and (C) leaves. (A) and (D) are isolated from Rheum palmatum Solvent system 2-propanol-elhyl acetate-water (36 36 28). Stationary phase POLYGRAM silica gel N-HR/UV254 (0.2 mm, MN). Developing distance 8.5 cm. Detection nitric acid/KOH reagent, visible lighlAJV-365. Band identities (I) aglycones (2) rhein (3) sennoside C (4) rhein-8-glucoside (5) sennoside D (6) sennoside B (7) sennoside A.

Figure 25 Separation of anthraquinone aglycones from Rheum palmatum. Solvent system light petroleum (40-60 C)-ethyi acetate-formic acid (75 25 1). Stationary phase silica gel 60 G (Merck, lab. prepared, 0,5 mm). Developing distance 18 cm. Detection absorbance at 420 nm. Peak identities (1) chrysophanol (2) physcione (3) emodin (4) rhein (5) aloe-emodin.

Polyphenols, such as quinones, are major components of many traditional herbal remedies which exhibit several beneficial effects, including antiinflammation. For example, Cuellar et al. [105] investigated the topical antiinflammatory activity of extracts from Cassia angustifolia Vahl. and Rheum palmatum, medicinal plants commonly known for their anthraquinonic content, and used in traditional East Asian medicine against different skin disorders. All the extracts significantly inhibited the edema induced by 12-0-tetradecanoylphorbol-13-acetate (TP A) in both single or multiple applications. 

The main anthraquinone-containing plants are cascara sagrada Rhamnus purshiana), senna, rhubarb, aloes, dock and St John s wort. Rheum-emodin is a typical simple anthraquinone from rhubarb root Rheum palmatum). 

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