Antagonism of kinin formation and action

Antagonism of Kinin Formation and Action We have seen above (page 62) that bradykinin may be the intermediate factor responsible for many of the manifestations of inflammation. It is natural to consider the possibility that anti-inflammatory drugs may inhibit either the formation or the action of bradykinin. 

Northover and Subramanian report that formation of kinin by serum and salivary kallikrein is inhibited by sodium salicylate, acetylsalicylic acid, phenylbutazone and certain other anti-inflammatory substances. The vasodepressor and vascular permeability activities of kallikrein are similarly inhibited. These findings are not, however, supported by investigations of other workers and further studies are needed to clarify the discrepancy. It is interesting to note that hexadimethrine bromide(polybrene), which is known to inhibit kinin formation in vitro, inhibits increased capillary permeability in the xylene treated skin of mice . 

despite the curious tissue and species specificity of the action of nonsteroidal anti-inflammatory compounds on bradykinin action, it is impossible to dismiss the connection as being fortuitous. 

---