Anileridine dihydrochloride

Chemical Name 1-[2-(4-aminophenyl)ethyl]-4-phenyl-4-piperldinecarboxylic acid ethyl ester dihydrochloride 

A mixture of 7.8 grams (0.05 mol) of/3-(p-aminophenyl)ethyl chloride hydrochloride, 12.5 grams (0.025 mol) of 4-phenyl-4-carboethoxypiperidine carbonate, 10.5 grams (0.125 mol) sodium bicarbonate, and 100 cc of anhydrous ethanol are mixed, stirred and heated under reflux for a period of approximately 40 hours and then concentrated in vacuo to dryness. The residual material is triturated with 50 cc of water, decanted, washed by decantation with an additional 50 cc of water, and then dried in vacuo to give N-[/3-(p-aminophenyl)-ethyl] -4-phenyl-4-carboethoxypiperidine. 

The N-[/3-(p-aminophenvl)ethvl]-4-phenyl-4-carboethoxypiperidine is dissolved in 50 cc of hot anhydrous ethanol, an excess (about 20 cc) of 20% alcoholic hydrochloric acid solution is added upon scratching the side of the container crystals form. One hundred cubic centimeters of ether are then added to the mixture, the ethereal mixture is cooled, and the crystalline material which precipitates is recovered by filtration, washed with ether, and dried to give 12.7 grams of N-[ 3-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine dihydrochloride which can be further purified by recrystallization from ethanol or methanol to give substantially pure material MP 275°-277°C. 

Chemical Name L-asparaginyl-L-arglnvI-L-valvI-L-tyrosyl-L-valvI-L-histidvl-L-protyl-L-phenylalanine 

L-Asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine methyl ester trihydrochloride Sodium hydroxide 

L-Asperaginyl-L-arginyl-L-velyl-L-tyrosyl-L-velyl-L-hlstIdyl-L-prolyl-L-phenylelenine methyl ester trihydrochloride Sodium hydroxide 

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