Anileridine

Anileridine, ethyl l-(4-amino phenethyl)-4 phenylisonipecotate is available in the form of its dihydrochloride for oral administration and as the phosphate for injection (Leritine ). Its analgesic potency is intermediate between that of meperidine and morphine. Similar to meperidine, it exerts mild antihistaminic and spasmolytic effects, but it is devoid of the constipating effect of opiates. Sedative and direct hypnotic effects are similar to those of meperidine but less than those of morphine. 

Anileridine hydrochloride is administered orally in the form of 25 mg tablets repeated every 6 h if necessary, but dosages up to 50 mg or more frequent doses may be desirable for more severe pain. Anileridine phosphate is administered by subcutaneous, intramuscular, or intravenous injection in doses of 25 to 50 mg (1 to 2 ml) at intervals of 4 to 6 h. 

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Alkylation of that amine with p-(2-chloroethyl)aniline affords anileridine (82), an analgesic similar to the parent compound but somewhat more potent. In similar fashion alkylation by means of w-(2-chloroethyl)morpholine gives morpheridine (83), while the use of 2-(chloroethyl)-ethanol yields carbethl-... 

Anagesterone acetate 2, 165 Anagrelide 244 Androstanolone 173 Anidoxime 125 Anileridine 1, 300 Anilopam T21 Anisindandione j, 147 Anitrazafen 2 ... 

Aminopyrine, 234 Aminotetradine, 265 2-Aminothiazole, 247 2-Aminothiazole synthesis, 126 Amisotetradine, 266 Amobarbital, 268 Amopyroquine, 342 Amoxycillin, 414 Amphetamine, 37, 70 Ampicillin, 413 Amprolium, 264 Amytriptylene, 141, 404 Anabolic effects, 169 Androgens, discovery, 155 Androstanolone, 173 Androstenedione, 158, 176 Anesthesia, parenteral, 56 Angst, 363 Anileridine, 300 Aniline, metabolism. 111 Anisindandione, 147 Anovlar , 186 Antagonists, 20, 65 Antazoline, 242 Antibodies, 41... 

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