Angiotensin converting enzyme angioedema

Captopril, many others Inhibit angiotensin converting enzyme Reduce angiotensin II levels reduce vasoconstriction and aldosterone secretion increase bradykinin Hypertension heart failure, diabetes Oral Toxicity Cough, angioedema teratogenic... 

Sadeghi N, Panje WR. Life-threatening perioperative angioedema related to angiotensin-converting enzyme inhibitor therapy. J Otolaryngol 1999 28(6) 354-6. 

Jacobs RL, Hoberman LJ, Goldstein HM. Angioedema of the small bowel caused by an angiotensin-converting enzyme inhibitor. Am J Gastroenterol 1994 89(l) 127-8. 

Brown NJ, Ray WA, Snowden M, Griffin MR. Black Americans have an increased rate of angiotensin converting enzyme inhibitor-associated angioedema. Chn Pharmacol Ther 1996 60(1) 8-13. 

Burkhart DG, Brown NJ, Griffin MR, Ray WA, Hammerstrom T, Weiss S. Angiotensin converting enzyme inhibitor-associated angioedema higher risk in blacks than whites. Pharmacoepidemiol Drug Sat 1996 5(3) 149-54. 

Abbosh J, Anderson JA, Levine AB, Kupin WL. Angiotensin converting enzyme inhibitor-induced angioedema more... 

ACE-I block the conversion of angiotensin 1 to angiotensin II, which causes vasoconstriction and stimulates the production of aldosterone synthesis. Thus, ACE-1 promote vasodilatation and decrease sodium retention, consequently lowering blood pressure. The inhibition of angiotensin-converting enzymes also blocks the breakdown of bradykinins. The increase in bradykinin level leads to additional vasodilatation effects. However, the increase in bradykinin is also responsible for adverse effects such as cough and angioedema. 

Angiotensin antagonists (Angiotensin-converting enzyme inhibitors) and ACE inhibitors lower blood pressure and are used to treat heart failure by causing the excretion of sodium and water. ACE inhibitors block the release of aldosterone. Aldosterone causes the retention of sodium. Cardiac output and heart rate remain unchanged. ACE inhibitors are administered to patients with elevated serum rennin levels. ACE inhibitors can cause angioedema in which the mouth, throat, lips, eyelids, hands, and feet swell. 

Angiotensin-converting enzyme inhibitors are effective in the treatment of hypertension and congestive heart failure. ACE inhibitors also prevent bra-dykinin metabolism and, as a result, may produce the side effect of cough and angioedema. Many of the known ACE inhibitors were developed without the aid of computational chemistry techniques. However, a number of studies have used computational methods to design mimics of other nonpeptidic ACE inhibitors. 

Miller DR, OUveria SA, Berlowitz DR, Fincke BG, Stang P, Lillienfeld DE. 2008. Angioedema incidence in US veterans initiating angiotensin-converting enzyme inhibitors. Hypertension 51 1624-1630. 

Duct obstruction Angiotensin-converting enzyme (ACE) inhibitors, for example, enalapril (angioedema) and ceftriaxone (gallstones)... 

Bas M, Greve J, Stelter K, Bier H, Stark T, Hoffmann TK, Kojda G. Therapeutic efficacy of icatibant in angioedema induced by angiotensin-converting enzyme inhibitors a case series. Ann Emerg Med 2010 56 278-82. 

GaUiteUi M, Alzetta M. Icatibant a novel approach to the treatment of angioedema related to the use of angiotensin-converting enzyme inhibitors. Am J Emerg Med 2012 30 1664—72. 

Hassen GW, Kalantari H, Parraga M, Chirurgi R, Meletiche C, Chan C, et al. Fresh frozen plasma for progressive and refractory angiotensin-converting enzyme inhibitor-induced angioedema. J Emerg Med 2013 44 764-72. 

Angiotensin converting enzyme inhibitors angioedema (Chapter 20) Angiotensin II receptor antagonists angioedema (Chapter 20) Antipsychotic drugs hyperprolactinemia (Chapter 6)... 

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