Angina pectoris adrenergic receptor

The therapeutic action of 3-adrenergic receptor blockers such as propranolol in angina pectoris is believed to be primarily the result of... 

Alpha-adrenergic antagonists are used primarily as antihypertensive drugs because of their ability to block vascular alpha-1 receptors. Beta-adrenergic antagonists (beta blockers) are administered primarily for their inhibitory effects on myocardial function and are used in the prevention and treatment of hypertension, angina pectoris, arrhythmias, and myocardial reinfarction. Many of the drugs introduced in this chapter are discussed further in chapters that deal with the specific clinical conditions (e.g., hypertension, asthma, and other disorders). 

Trade names Apo-Nadolol Corgard Corzide (Monarch) Farmagard Nadic Solgol Syn-Nadolol Indications Hypertension, angina pectoris Category Adrenergic beta-receptor antagonist Antiarrhythmic class II... 

In view of the known actions of catecholamines on the myocardium and from the observation that the Individual with angina pectoris has a hyperactive sympathetic system, it is rationalized that blockade of the beta adrenergic receptors may benefit the anginal patient. There are a number of agents which produce a selective blockade of the beta adrenergic receptor, their structure activity relationships have been reviewed. 

Nadolol is a nonselective beta-adrenergic-receptor-blocking agent that possesses no intrinsic sympathomimetic activity. It is indicated in angina pectoris (120 mg/day) and in combination with other antihypertensive medications in the... 

Task forces from the ACC and the AHA have published guidelines that are useful in the selection of appropriate initial therapy for patients with chronic stable angina pectoris (www.americanheart.org). Patients with coronary artery disease should be treated with aspirin and a P adrenergic receptor antagonist (particularly if there is a history of prior MI). The guidelines also... 

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