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Andrographolides

Andrographolide A Plant-Derived Natural Molecule of Pharmaceutical Promise... [Pg.335]

Andrographolide, a labdane-diterpenoid lactone, is the principal bioactive chemical constituent of Andrographis paniculata (Brum. F.) Nees (family Acanthaceae) this prime constituent is mainly concentrated in leaves and can easily be isolated from the crude plant extracts as crystalline... [Pg.335]

Andrographolide — A Molecule of Pharmaceutical Promise 337 3. Pharmaceutical Potential... [Pg.337]

Andrographolide exhibits a vast range of biological activities as reported so far. This section focuses on such promising pharmaceutical potentials of the bioactive natural molecule. [Pg.337]

The diterpenes andrographolide, andrographiside and neoandro-grapholide isolated from A. paniculata were also investigated for their protective effects on hepatotoxicity induced in mice by carbon tetrachloride or /ert-butylhydroperoxide ( BHP) intoxication by Kapil et pretreatment of mice with the individual diterpenes at a dose of 100 mg/kg, i.p. for 3 consecutive days were observed to produce significant reduction in malondialdehyde formation, reduced glutathione (GSH) depletion and... [Pg.337]

Andrographolide, thus, has different mechanisms of anti-inflammatory activity. It can inhibit the activation of NF-kB, suppress inducible nitric oxide synthase (iNOS) expression, inhibit COX-2 expression in human fibroblast cells and also prevent oxygen radical production by human. The compound is also able to modulate T-cell activation both in vitro as well as in vivo, it is evident that it could prevent initial T-cell priming by interfering with DC maturation and antigen presentation capacity. Therefore, andrographolide may have utility as a therapeutic agent for the treatment of autoimmune diseases, such as multiple sclerosis. " ... [Pg.343]

Li et investigated the effect of andrographolide on virulence factors production in Pseudomonas aeruginosa it was found that the production... [Pg.348]

Scheme 1. Proposed metabolic path of andrographolide in rats. (He et a/. ")... Scheme 1. Proposed metabolic path of andrographolide in rats. (He et a/. ")...
Scheme 2. Structures of glucuronide conjugates of andrographolide in human urine and possible metabolic pathways for their production. (Cui et... Scheme 2. Structures of glucuronide conjugates of andrographolide in human urine and possible metabolic pathways for their production. (Cui et...
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See also in sourсe #XX -- [ Pg.331 ]



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Andrographolide

Andrographolide from Andrographis paniculata

Neoandrographolide (andrographolide

Succinoyl-andrographolide

Succinoyl-andrographolide effects on furin

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