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And narcolepsy

Brown, R. E. (2003). Involvement of hypocretins/orexins in sleep disorders and narcolepsy. Drug News Perspect. 16, 75-9. [Pg.48]

Hungs, M. Mignot, E. (2001). Hypocretin/orexin, sleep and narcolepsy. Bioessays 23, 397-408. [Pg.399]

In 1970, the U.S. government passed the original Controlled Substances Act, and under this law methamphetamine was classified as a Schedule II drug in its injectable form and a Schedule III in its noninjectable (pill) form. However, a year later, both forms of methamphetamine were reclassified as Schedule II drugs. Today, it is still sold under the name Des-oxyn for a few medical uses, such as for the treatment of atten-tion-deficit/hyperactivity disorder (ADHD) and narcolepsy. [Pg.19]

MPH is an amphetamine-like prescription stimulant commonly used to treat Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy in children and adults. LC/APCI-MS enantiomeric separations of racemic MPH (Ritalin ) were reported using a commercially available vancomycin CSP [111-113]. [Pg.150]

Poor Timing of Neurotransmission. The activity of some brain circuits, like the secretion of certain hormones, varies at certain times of the day. Called circadian rhythms, the timing of these rhythms may be disrupted in some illnesses. Examples include sleep disorders such as insomnia and narcolepsy, as well as other conditions such as nighttime binge-eating disorder. [Pg.21]

The discussion that follows will be limited to those sleep disorders that are common in adults and that frequently require medication as part of the usual treatment. Specifically, we will discuss insomnia and narcolepsy (the most common hypersomnia). We will briefly mention treatments for the nighttime limb movement disorders. [Pg.260]

Stimulants are a class of psychoactive medications approved by the U.S. Food and Drug Administration (FDA) for use in the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents and narcolepsy. A hst of available stimulants is shown in Table 6-1. [Pg.171]

Methamphetamine, a Schedule 11 drug, was first synthesized in 1919. It can be synthesized from ephedrine or pseudo-ephedrine. Methamphetamine is available by prescription for weight control, ADHD, and narcolepsy under the brand name Desoxyn . Street names for methamphetamine include chalk, crank, crystal, fire, glass, ice, rocks, shabu, speed, and yaba. Methamphetamine is often found at rave sites, where people exert themselves while dancing and deprive themselves of sleep, food, and drink, which can result in increased body temperature with excessive sweating and possibly a salt imbalance. [Pg.65]

Because of its misuse especially by teenagers, its use is limited to the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy. [Pg.138]

Investigation and diagnosis of sleep disorders, especially sleep apnea and narcolepsy... [Pg.18]

As an aside, in March of 2005, Abbott Laboratories, the maker of Cylert , decided to take its drug off the U.S. market because of increasing concerns about it causing liver problems. Cylert had been available in the United States for 30 years for the treatment of ADHD and narcolepsy. However, the generic form of Cylert (pemoline) is still available. [Pg.84]

Figure 25-8 Baseline separation of enantiomers of the drug Ritalin by HPLC with a chiral stationary phase. One enantiomer is pharmacologically active for treating attention deficit disorder and narcolepsy. The other enantiomer has little activity but could contribute to undesired side effects. Pharmaceutical companies are moving toward providing enantiomerically pure drugs, which could be safer than mixtures of optical isomers. [From R. Bakhtiar, L Ramos, and F. L. S. Tse, "Quantification of Methylphenidate in Plasma Using Chiral Uquid-Chromatography/Tandem Mass Spectrometry Application to Taxicokinetic Studies," Anal. Chim. Acta 2002, 469.261.]... Figure 25-8 Baseline separation of enantiomers of the drug Ritalin by HPLC with a chiral stationary phase. One enantiomer is pharmacologically active for treating attention deficit disorder and narcolepsy. The other enantiomer has little activity but could contribute to undesired side effects. Pharmaceutical companies are moving toward providing enantiomerically pure drugs, which could be safer than mixtures of optical isomers. [From R. Bakhtiar, L Ramos, and F. L. S. Tse, "Quantification of Methylphenidate in Plasma Using Chiral Uquid-Chromatography/Tandem Mass Spectrometry Application to Taxicokinetic Studies," Anal. Chim. Acta 2002, 469.261.]...
Yoss RE, Moyer NJ, Ogle KN. The pupillogram and narcolepsy a method to measure decreased levels of wakefulness. Neurology 1969 19 921-928. [Pg.22]

Findley LJ, Suratt PM, Dinges DF. Time-on-task decrements in steer clear performance of patients with sleep apnea and narcolepsy. Sleep 1999 22 804-809. [Pg.63]

Taheri S, Zeitzer JM, Mignot E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu Rev Neurosci 2002 25 283-313. [Pg.143]

Of the 88 sleep disorders listed in the International Classification of Sleep Disorders (12), the better-known and more prevalent disorders are the obstructive sleep apnea syndrome, insomnia, restless legs syndrome/periodic limb movement disorder, and narcolepsy (see also Chap. 5).These sleep disorders are common, and are known to interfere with the quality of sleep this chapter addresses the socioeconomic impact of these disorders. [Pg.215]

Broughton RJ, Guberman A, Roberts J. Comparison of the psychosocial effects of epilepsy and narcolepsy/cataplexy a controlled study. Epilepsia 1984 25(4) 423 133. [Pg.228]

Bastuji H, Jouvet M. Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. Prog Neuro-psychopharmacol Biol Psychiatry 1988 12 695-700. [Pg.444]

Lammers GJ, Arends J, Declerk AC (1993) Gammahydroxybutyrate and narcolepsy a double- blind placebo-controlled study. Sleep 16 216-220... [Pg.58]

Methylphenidate was synthesized in 1944 in Europe in an unsuccessful attempt to create a stimulant that would not produce addiction or tolerance (Figure 1.1). Introduced in the United States in 1955, it was first approved by the FDA for the treatment of drug-induced lethargy, mild depression, and narcolepsy. In the early 1960s, the drug was first marketed under the name Ritalin to improve memory in elderly patients and to treat several behavioral problems in children. [Pg.12]

Burlet S, Tyler CJ, Leonard CS (2002) Direct and indirect excitation of laterodorsal temental neurons by hypocretin/orexin peptides implications for wakefulness and narcolepsy. J Neurosci 22 2862-72... [Pg.430]

The armodafinil development program was very similar to the development program previously undertaken for modafinil (or racemic API). Four double-blind and two opened-label clinical trials (1090 patients enrolled with 645 receiving active treatment with armodafinil and 445 receiving placebo) have evaluated the efficacy and safety of armodafinil for the treatment of excessive sleepiness (ES) associated with obstructive sleep apnea (OSA), shift-work disorder (SWD), and narcolepsy.24... [Pg.295]


See other pages where And narcolepsy is mentioned: [Pg.264]    [Pg.48]    [Pg.56]    [Pg.200]    [Pg.227]    [Pg.427]    [Pg.428]    [Pg.51]    [Pg.111]    [Pg.173]    [Pg.178]    [Pg.179]    [Pg.234]    [Pg.178]    [Pg.167]    [Pg.22]    [Pg.56]    [Pg.570]    [Pg.38]    [Pg.45]   
See also in sourсe #XX -- [ Pg.76 , Pg.156 , Pg.167 , Pg.168 , Pg.169 , Pg.170 ]

See also in sourсe #XX -- [ Pg.76 , Pg.156 , Pg.167 , Pg.168 , Pg.169 , Pg.170 ]




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