And biological activities of condensed

Synthesis and Biological Activities of Condensed Heterocyclofn, m-a, b, or cJQuinazolines... 

Synthesis, set also Heterocyclic synthesis and biological activities of condensed heterocycloln.m-tj, b, or cjquinazolines. 52, I and reactions of l-azirines, 13, 45 of condensed l,2,4-triazolo[3,4-z)heterocycles, 49, 277 by ring-closure of o-substituted t-anilines, 14, 211... 

The domino process probably involves the chiral enamine intermediate 2-817 formed by reaction of ketone 2-813 with 2-815. With regard to the subsequent cy-doaddition step of 2-817 with the Knoevenagel condensation product 2-816, it is interesting to note that only a normal Diels-Alder process operates with the 1,3-bu-tadiene moiety in 2-817 and not a hetero-Diels-Alder reaction with the 1-oxa-l,3-butadiene moiety in 2-816. The formed spirocydic ketones 2-818/2-819 can be used in natural products synthesis and in medidnal chemistry [410]. They have also been used in the preparation of exotic amino adds these were used to modify the physical properties and biological activities of peptides, peptidomimetics, and proteins... 

The biological activities of condensed pyrimidine systems as diuretics, antitumor agents or as antagonists of constituents of nucleic acid and of folic-folinic acid family of vitamins prompted differents authors to study the synthesis of cyclic six membered acylureas such as pyrido[2,3-d] pyrimidinones (Ref. 266). 

Benzotriazepinones, chemistry and biological activity of 84PHA310. Monocyclic and condensed triazepines and tetrazepines, general reviews ... 

A first attempt to an estimation of the contribution of benzo(a)pyrene of the total biological activity of condensates is recording their PAH-profiles. Typical profiles from OTTO- and DIESEL-engines after Europates t cycles are given in figures 5 and 6 ... 

Glycosylurea and thiourea derivatives, e.g. (19), were synthesized by condensation of alkyl isocyanates and isothiocyanates respectively, with jS-D-glucopyranosylamine and fi-lactosylamine, as non-ionic detergents of particular interest for extraction of membrane proteins. Various l-( -D-glycosyl)-derivatives of diphenylhydantoin and hydrochlorothiazide were synthesized in an attempt to enhance the hydrophilicity and biological activity of these materials. Conformation analysis and X-ray structures of some 1,2- and 1,3-fused glycosylamine derivatives are included in Chapters 21 and 22. 

Condensation of N -substituted hydroxylamines with aldehydes and ketones is widely used in the synthesis of various spin traps and biologically active nitrones (Fig. 2.5) (161-186). 

The biological activity of azoles and their derivatives (indoles, purines, etc.) and their abundance as structural motif in natural products made them a prime target and test ground in the development of catalytic transformations. This chapter is mainly dedicated to the reactions of monocyclic five membered heterocycles and indole. The chemistry of other condensed systems of importance, such as purines, is discussed in Chapter 8. 

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