Analytical chemistry spectroscopy

PUZZLES Using spectroscopy to (determine the structure of an unknown organic molecule is very much like putting together the pieces of a jigsaw puzde. 

After a great expenditure of life and treasure a Daring Explorer had succeeded in reaching the North Pole, when he was approached by a Native Galeut who lived there. 

But the Scientist of the Expedition explained that he had been so engrossed with the care of his instruments and the study of his tables that he had found no time to think of it. 

PROBLEM 15.1 How would a separation of enantiomers be possible Are not all physical properties (except, of course, for the direction of rotation of the plane of plane-polarized light) identical for enantiomers Can you guess the principle on which the chromatographic separation of enantiomers must rest Hint What is true for enantiomers is not necessarily true for diastereomers (p. 169). 

FIGURE 15.1 (a) A schematic view of a liquid chromatograph, (b) A chromatogram showing the separation of a mixture of organic compounds into its components. 

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Siegel S, Boggs B, and Falls H (2003) Utilization of ICP-AES for the analysis of phosphate fertilizers. Paper presented to the Phosphate Conference, October 16, Lakeland, Florida, and Federation of Analytical Chemistry Spectroscopy Societies in Ft. Lauderdale, Florida, October 19-23. Visit website http //afpc.net to obtain a free copy. 

Although this book concentrates on organic chemistry examples, be aware that the study of spectroscopy crosses over into many areas, inclnding biochemistry, inorganic chemistry, physical chemistry, materials chemistry, and analytical chemistry. Spectroscopy is an indispensible tool to support all forms of laboratory research. 

The pioneering works in chemometrics are summarized in some books. In a later phase chemometrics has been presented more fundamentally. Nowadays a series of books for the different aspects of chemometrics are available, such as in analytical chemistry, spectroscopy, calibration, quantitative structure-activity relationships, experimental design, chemical structures, organic synthesis, and neural networks. Research papers in chemometrics are widespread but some concentration occurs in journals of analytical chemistry, chromatography, spectroscopy, and computer chemistry. Two journals have the word chemometrics in their name Chemometrics and Intelligent Laboratory Systems and Journal of Chemometrics. Comprehensive reviews about chemometrics in analytical chemistry have appeared since 1980 every two years 1982, 1984, 1986, 1988, 1990, 1992, 1994, and 1996. ... 

B. D. Gardner, J. F. Holland, D. G. Patterson, Jr., and J. Grainger, Rapid environmental toxicant screening using multi-dimensional GC-tune-of-flightmass spectrometry, presented at 23rd Annual Conf. Fed. Analytical Chemistry Spectroscopy Societies, Kansas City, MO, Sept. 29-Oct. 4, 1996. 

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