Tandem mass spectrometry analytical characteristics

Analytical characteristics, tandem mass spectrometry, 127-29 Analytical method, volatile aldehydes, 61-77 Apple essence... 

Principles and Characteristics Analytical multistage mass spectrometry (MSn) relies on the ability to activate and dissociate ions generated in the ion source in order to identify or obtain structural information about an unknown compound and to analyse mixtures by exploiting two or more mass-separating steps. A basic instrument for the currently most used form, tandem mass spectrometry (MS/MS), consists of a combination of two mass analysers with a reaction region between them. While a variety of instrument set-ups can be used in MS/MS, there is a single basic concept involved the measurement of the m/z of ions before and after a reaction in the mass spectrometer the reaction involves a change in mass and can be represented as ... 

Quadrupole ion trap mass analyzers merge the trapping characteristics of the ICR with the physical principles of the linear quadrupole mass analyzer. Quadrupole ion traps produce time-dependent spectra with excellent sensitivity and tandem mass spectrometry capabilities, but unlike the ICR they provide these ion trapping characteristics with physically smaller and considerably less expensive instrumentation, giving them a reputation as a powerful and accessible tool for both qualitative and quantitative mass spectrometry [43-47]. The capability of quadrupole ion traps to be configured with either internal and external ionization sources has expanded their utility for modem analytical applications [48—52]. 

Tandem mass spectrometry (MS/MS) might be an alternative to high resolution MS under some circumstances (e.g., when detection with very high sensitivity is required in a complex matrix). In MS/MS, an ion characteristic for the analyte molecule is selected (so-called parent ion)... 

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