Analog design limitations

Low water solubility, less potency against dmg-resistant HIV strains, and fast metabolism are three main obstacles that limit the development of DCK analogs. Additional analog design is likely to use DCP as a new lead to increase the potency against drug-resistant viral strains and improve water solubility and pharmacological properties. 

Radiant heat flux is defined as heat intensity on a specific tube surface. Thus, heat flux represents the combustion intensity and is analogous to how hard a fired heater is run. More specifieally, keeping the firing rate within safe limits is equivalent to maintaining the peak heat flux at less than the design limit because high firebox temperatures could cause tubes, tube-sheet support, and refiractory failures. What is the peak flux and why is it so important to keep it within the limit These questions will be answered next. 

This expression is the sum of a transient tenu and a steady-state tenu, where r is the radius of the sphere. At short times after the application of the potential step, the transient tenu dominates over the steady-state tenu, and the electrode is analogous to a plane, as the depletion layer is thin compared with the disc radius, and the current varies widi time according to the Cottrell equation. At long times, the transient cunent will decrease to a negligible value, the depletion layer is comparable to the electrode radius, spherical difhision controls the transport of reactant, and the cunent density reaches a steady-state value. At times intenuediate to the limiting conditions of Cottrell behaviour or diffusion control, both transient and steady-state tenus need to be considered and thus the fiill expression must be used. Flowever, many experiments involving microelectrodes are designed such that one of the simpler cunent expressions is valid. 

The safety principles and criteria used ia the design and constmction of the faciUties which implement the nuclear fuel cycle are analogous to those which govern the nuclear power plant. The principles of multiple barriers and defense-ia-depth are appHed with rigorous self-checking and regulatory overview (17,34). However, the operational and regulatory experience is more limited. 

The first issue can be addressed in two ways a primary ET species which has a large optical absorption cross-section can be chosen or arrays of molecules with large optical absorption cross-sections can be used as "antennas" that will efficiently collect and transport the electronic excitation energy to the primary ET species, in direct analogy to photosynthetic systems. While in the latter case it should be possible to develop systems with more efficient solar photon collection, the number of primary ET species will have to be reduced due to the spatial limitations, which will also reduce the potential electric current that can be produced by the system. Thus, questions related to the detailed molecular architecture of biomimetic solar energy conversion devices will have to address this issue, and it is quite likely that a number of compromises will have to be made before optimal design characteristics are obtained. 

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