Amyloid plaques and

In fact no consistent correlation has been found between the appearance, distribution and number of amyloid plaques and either neuronal loss or the degree of dementia, although the latter correlates with the number of neurofibrillary tangles, which tend to precede plaques in appearance by some years. Also cortical amyloid deposits can be found in non-demented elderly patients. Thus the basic question appears to be does the disease process, whatever that is, cause the development of AzD as well as the production of jS-amyloid or is there production of S-amyloid, which then causes AzD Consensus supports the latter but it is not proven. 

Today AD can be easily recognized when memory and other cognitive and behavioural deficit are sufficiently severe to interfere with normal daily activities. Unfortunately, at this point in the patient s lifetime, the accumulation of amyloid plaques and... 

Both amyloid plaques and the tangles of protein tau-containing paired helical filaments are typically present in Alzheimer disease. Which comes first ... 

Alzheimer s disease (AD) is one of the most common forms of dementia that affect the elderly population. The histopathological hallmarks of AD are extracellular deposits known as neuritic amyloid plaques and intraneuronal inclusions composed of hyperphosphorylated tangles enriched with tau proteins.1 The principal component of the neuritic plaques is aggregation of amyloid (A0), which is likely to play a role in the neurodegenerative process. The relative contribution of the various forms (soluble dimers, small oligomers, protofibrils, and fibrils) of A0 to neuronal... 

A protein infectious agent that is thought to promote misfolding and polymerization of normal protein molecules, leading to amyloid plaques and destruction of nerve tissue, (p. 1194)... 

Hydroxyethylene analogs, (I), effective as (3-secretase enzyme inhibitors prepared by Horn (2) were effective in treating amyloid plaques and slowing the progression of Alzheimer s disease. 

H, Giacobini E, de Vos RA, Steur EN, Maelicke A, Albuquerque EX, Schroder H (1999) Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer s disease histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein. Eur J Neurosci 11 2551-2565... 

Neurodegeneration is an important but not a unique characteristic feature of AD. What distinguishes AD from other neurodegenerative diseases is the presence of its telltale pathologies in the brains of these patients amyloid plaques and neurofibrillary tangles (NFTs). Amyloid plaques consist of mainly extracellular /f-amyloid (A/i) peptide while neurofibrillary tangles are... 

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