Amyloid fibril protein

Dische FE, Wemstedt C, Westermark GT, Westermark P, Pepys MB, Rennie JA, Gilbey SG, Watkins PJ. Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient. Diabetologia 1988 31(3) 158-61. 

Kitamoto, T., Tateishi, J., Hikita, K., Nagara, H., and Takeshita, I. 1985. A new method to classify amyloid fibril proteins. Acta Neuropathol. (Berl). 67 272-278. 

L15. Linke, R. P., Sipe, J. D., Pollock, P. S, Ignaczak, T. F., and Glenner, G. G., Isolation of a low-molecular-weight serum component antigenically related to an amyloid fibril protein of unknown origin. Proc. Natl. Acad. Sci. U.S.A. 72, 1473-1476 (1975). 

Sletten, K., and Husby, G., The complete amino acid sequence of non-immunoglobulin amyloid fibril protein AS in rheumatoid arthritis. Eur. J. Biochem. 41, 117-125 (1974). 

M6. Maruyama, K., Kametani, F., Ikeda, S., Ishihara, T., and Yanagisawa, N., Characterization of amyloid fibril protein from a case of cerebral amyloid angiopathy showing immunohistochemical reactivity for both 3 protein and cystatin C. Neurosci. Lett. 144(1-2), 38-42 (1992). 

Not only the ultimate speed but also the safety of operation are very important considerations in MAS NMR. For example, isotopically labelled biopolymers are not only very expensive, but may also pose a serious health hazard if a rotor containing a sample such as amyloid fibril protein disintegrates in the laboratory. 

Glenner, G.G., and Wong, C.W. (1984). Alzheimer s disease and Down s syndrome shar-inc of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 122, 1131-1135. 

Galea C, Bowman P, Kriwacki RW (2005) Disruption of an intermonomer salt bridge in the p53 tetrameriza-tion domain results in an increased propensity to form amyloid fibrils. Protein Sci 14 2993-3003 Ganesh S, Tayakumar R (2003) Structural transitions involved in a novel amyloid-like beta sheet assemblage of tripeptide derivatives. Biopolymers 70 336-345... 

Costa, P. P., Figueira, A. S., and Bravo, F. R. (1978). Amyloid fibril protein related to prealbumin in familiai amyloidotic polyneuropathy. Proc. NatL Acad. Sci. U.S.A. 75,4499-4503. 

Amyloid fibril protein typing in 132 localized cases revealed 120 AL (91%), 8 AA (6%), 3 ATTR (2%), and 1 AB2M (55). All analyzed lung-related cases have been composed of light chain (AL) immunoglobulin, typically encompassing the variable region of k1 or Xlll (61-63). The presence of clonal plasma... 

The link of structure and dynamics of biomolecules and their complexes to their function and to many cellular processes has driven the quest for their detailed characterization by a variety of biophysical techniques. Solid-state MAS NMR spectroscopy provides rich information on the structural properties of such systems and in particular contributes invaluable information on non-soluble, large molecular-weight and non-crystalline biomolecules. The review article by Goldbourt summarizes the recent progress that has been made in the characterization of macromolecular assemblies, viruses, membrane proteins, amyloid fibrils, protein aggregates and more by solid-state MAS NMR. ... 

---